ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Single tick bite can pack double pathogen punch

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Higher vitamin D levels associated with better cancer prognosis

Genetic study suggests causal link between vitamin D deficiency and hypertension

Unsuspected aspect of immune regulation revealed: Role of B cells

Explaining 'Healthy' Obesity

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

 
Print Page
Email Article

Coenzyme Q10 distribution in blood is altered in patients with Fibromyalgia - Source: Clinical Biochemistry, Dec 25, 2008

  [ 7 votes ]   [ 2 Comments ]
By MD Cordero, P Navas, et al. • www.ProHealth.com • January 12, 2009


Objective: Coenzyme Q10 (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs and symptoms associated with muscular alteration and mitochondrial dysfunction, including oxidative stress, have been observed in patients with fibromyalgia (FM).

The aim was to study CoQ(10) levels in plasma and mononuclear cells, and oxidative stress in FM patients.

Methods: We studied CoQ(10) level by HPLC in plasma and peripheral mononuclear cells obtained from patients with FM and healthy control subjects. Oxidative stress markers were analyzed in both plasma and mononuclear cells from FM patients.

Results:
• Higher level of oxidative stress markers in plasma was observed respect to control subjects.

• CoQ(10) level in plasma samples from FM patients was doubled compared to healthy controls

• And in blood mononuclear cells [immune cells – e.g., Natural Killer, T and B cells] isolated from 37 FM patients was found to be about 40% lower.

• Higher levels of ROS [reactive oxygen species, aka free radical] production was observed in mononuclear cells from FM patients compared to control, and a significant decrease was induced by the presence of CoQ(10).

Conclusion:
• The distribution of CoQ(10) in blood components was altered in FM patients.

• Also, our results confirm the oxidative stress background of this disease probably due to a defect on the distribution and metabolism of CoQ(10) in cells and tissues.

• The protection caused in mononuclear cells by CoQ(10) would indicate the benefit of its supplementation in FM patients.

Source: Clinical Biochemistry, Dec 25, 2008. E-pub ahead of print. PMID: 19133251, by Cordero MD, Moreno-Fernández AM, Demiguel M, Bonal P, Campa F, Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez Alcázar JA, Salviati L, Navas P. Universidad Pablo de Olavide, Centro de Investigación Biomédica en Red de Enfermedades Raras, and Universidad de Sevilla, Sevilla, Spain; Clinical Genetics Unit and Oncology/Hematology laboratory, Department of Pediatrics, University of Padova, Italy. [E-mail: pnavas@upo.es]





Join the Discussion Post a Comment 


How much CoQ10 should someone with Fibromyalgia be taking?
Posted by: Dianneweiland
Jan 21, 2009
So, after reading this article, I'm wondering just how much CoQ10 a person with Fibromyalgia should be taking to offset the problem with distribution? I take 100mg a day, and I have Fibromyalgia. I've taken CoQ10 since I was in my twenties and I'm fifty-eight now, and have had Fibromyalgia since 1995, when I was forty-four. Since I was diagnosed, I've studied everything I could find on Fibro, to help learn to live with it, since no one has found a "cure" yet. I've tried all sorts of "protocols" which didn't help. I've taken medications which didn't hel and the side effects were as bad as the Fibro. So, I'm a little stymied by this research, which came up with a conclusion, but offerred no "help".
Reply Reply

confused
Posted by: AuntTammie
Jan 21, 2009
If the level of CoQ10 in the plasma was double that of controls, does that mean that the bodies of people with FM are producing more because they are unable to fully utilize what they make? If so, would supplements help, or would they just be getting wasted?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing