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Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome - Source: Science, Oct 8, 2009

  [ 71 votes ]   [ 2 Comments ]
By Vincent C Lombardi, Judy A Mikovits, et al. • • October 8, 2009

Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide.

Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in:

• 68 of 101 patients (67%),
• Compared to 8 of 218 (3.7%) healthy controls.

Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell associated and cell-free transmission of the virus are possible.

Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines following exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients.

These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.

Source: Science (online ScienceExpress, Oct 8, 2009 ), Lobardi VC, Ruscetti FW, Gapta JD, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA. Whittemore Peterson Institute, Reno, Nevada; Laboratory of Experimental Immunology, Laboratory of Cancer Prevention, Advanced Technology Program, and Basic Research Program - Scientific Applications International Corporation, National Cancer Institute-Frederick, Frederick, Maryland; Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. [E-mail:]

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Article Comments Post a Comment

Posted by: tgwill
Oct 12, 2009
I would like to thankyou for giving me hope again. I've had CEBV for 23 years and have also had to battle two cancers. I would be more than willing to take part in any of your further studies regarding your findings as I can not feel better soon enough and am always afraid some new cancer will appear. Again congratulations on helping many people feel there is a possible life ahead of them. Best Faith
Reply Reply

Posted by: tgwill
Oct 12, 2009
Hit the wrong thumb.Was meant to say highest score possible.This is a very tired day to be sure. Faith
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