ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Meet Your Weight Loss Goals

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

Alzheimer’s drug development focuses on raising good cholesterol – the secret of the ‘Longevity Gene’

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 4, 2010


“Most work on the genetics of Alzheimer’s disease has focused on factors that increase the danger. We reversed this approach and focused on a genetic factor that protects against age-related illnesses. - Richard B Lipton, MD

Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a “longevity gene” helps to slow age-related decline in brain function in older adults. Drugs that mimic the gene’s effect are now under development, the researchers note, and could help protect against Alzheimer’s disease.

The paper describing the Einstein study was published Jan 13 in the Journal of the American Medical Association.(1) “Most work on the genetics of Alzheimer’s disease has focused on factors that increase the danger,” said Richard B. Lipton, MD, vice chair of Einstein’s Neurology Department and senior author of the paper.

As an example, he cites APOE e4, a gene variant involved in cholesterol metabolism that is known to increase the risk of Alzheimer’s among those who carry it. “We reversed this approach,” says Dr. Lipton, “and instead focused on a genetic factor that protects against age-related illnesses, including both memory decline and Alzheimer’s disease.”

In a 2003 study, Dr. Lipton and his colleagues identified the cholesteryl ester transfer protein (CETP) gene variant as a “longevity gene” in a population of Ashkenazi Jews. The favorable CETP gene variant:

•  Increases blood levels of high-density lipoprotein (HDL) – the so-called ‘good’ cholesterol,

•  And also results in larger-than-average HDL and low-density lipoprotein (LDL) particles.

The researchers of the current study hypothesized that the CETP longevity gene might also be associated with less cognitive decline as people grow older.

To find out, they examined data from 523 participants from the Einstein Aging Study, an ongoing federally funded project that has followed a racially and ethnically diverse population of elderly Bronx residents for 25 years.

At the beginning of the study, the 523 participants - all of them 70 or over - were cognitively healthy, and their blood samples were analyzed to determine which CETP gene variant they carried. They were then followed for an average of four years and tested annually to assess their rates of cognitive decline, the incidence of Alzheimer’s disease and other changes.

“We found that people with two copies of the longevity variant of CETP had slower memory decline and a lower risk for developing dementia and Alzheimer’s disease,” says Amy E. Sanders, MD, assistant professor in Einstein’s Department of Neurology and lead author of the paper. “More specifically, those participants who carried two copies of the favorable CETP variant had a 70 percent reduction in their risk for developing Alzheimer’s disease compared with participants who carried no copies of this gene variant.”

The favorable gene variant alters CETP so that the protein functions less well than usual. Dr. Lipton notes that drugs are now being developed that duplicate this effect on the CETP protein.

“These agents should be tested for their ability to promote successful aging and prevent Alzheimer’s disease,” he recommends.

…The research was funded by the National Institute on Aging, one of the 27 institutes and centers of the National Institutes of Health.

__
1. Article: “Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia”

Source: Albert Einstein College of Medicine news release, Jan 12, 2010




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map