ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Strengthening DNA to Prevent Inflammation, Heart Disease, Dementia and More

Magnesium: Widespread Deficiency with Deadly Consequences

CoQ10: The Longevity Factor

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Omega-3 Fatty Acids Increase Brain Volume

Turmeric compound boosts regeneration of brain stem cells

Optimal Prostate Defense Requires a Multi-Modal Strategy

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

Extending Life and Fighting Disease with Resveratrol

Widely Used in Europe... Natural Sedative Restores Youthful Sleep

 
Print Page
Email Article

Alzheimer’s drug development focuses on raising good cholesterol – the secret of the ‘Longevity Gene’

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 4, 2010


“Most work on the genetics of Alzheimer’s disease has focused on factors that increase the danger. We reversed this approach and focused on a genetic factor that protects against age-related illnesses. - Richard B Lipton, MD

Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a “longevity gene” helps to slow age-related decline in brain function in older adults. Drugs that mimic the gene’s effect are now under development, the researchers note, and could help protect against Alzheimer’s disease.

The paper describing the Einstein study was published Jan 13 in the Journal of the American Medical Association.(1) “Most work on the genetics of Alzheimer’s disease has focused on factors that increase the danger,” said Richard B. Lipton, MD, vice chair of Einstein’s Neurology Department and senior author of the paper.

As an example, he cites APOE e4, a gene variant involved in cholesterol metabolism that is known to increase the risk of Alzheimer’s among those who carry it. “We reversed this approach,” says Dr. Lipton, “and instead focused on a genetic factor that protects against age-related illnesses, including both memory decline and Alzheimer’s disease.”

In a 2003 study, Dr. Lipton and his colleagues identified the cholesteryl ester transfer protein (CETP) gene variant as a “longevity gene” in a population of Ashkenazi Jews. The favorable CETP gene variant:

•  Increases blood levels of high-density lipoprotein (HDL) – the so-called ‘good’ cholesterol,

•  And also results in larger-than-average HDL and low-density lipoprotein (LDL) particles.

The researchers of the current study hypothesized that the CETP longevity gene might also be associated with less cognitive decline as people grow older.

To find out, they examined data from 523 participants from the Einstein Aging Study, an ongoing federally funded project that has followed a racially and ethnically diverse population of elderly Bronx residents for 25 years.

At the beginning of the study, the 523 participants - all of them 70 or over - were cognitively healthy, and their blood samples were analyzed to determine which CETP gene variant they carried. They were then followed for an average of four years and tested annually to assess their rates of cognitive decline, the incidence of Alzheimer’s disease and other changes.

“We found that people with two copies of the longevity variant of CETP had slower memory decline and a lower risk for developing dementia and Alzheimer’s disease,” says Amy E. Sanders, MD, assistant professor in Einstein’s Department of Neurology and lead author of the paper. “More specifically, those participants who carried two copies of the favorable CETP variant had a 70 percent reduction in their risk for developing Alzheimer’s disease compared with participants who carried no copies of this gene variant.”

The favorable gene variant alters CETP so that the protein functions less well than usual. Dr. Lipton notes that drugs are now being developed that duplicate this effect on the CETP protein.

“These agents should be tested for their ability to promote successful aging and prevent Alzheimer’s disease,” he recommends.

…The research was funded by the National Institute on Aging, one of the 27 institutes and centers of the National Institutes of Health.

__
1. Article: “Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia”

Source: Albert Einstein College of Medicine news release, Jan 12, 2010



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing