ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Epstein-Barr virus in bone marrow of rheumatoid arthritis patients predicts response to rituximab treatment – Source: Rheumatology (Oxford), Jun 14, 2010

  [ 36 votes ]   [ Discuss This Article ]
By M Magnusson, et al. • www.ProHealth.com • June 16, 2010


Objectives: Viruses may contribute to RA. This prompted us to monitor viral load and response to anti-CD20 therapy in RA patients. [The drug rituximab is an antibody against the protein CD20, found on the overactive B cells involved in the autoimmune activity of RA. In some patients, rituximab helps RA by depleting B cells.]

Methods: Blood and bone marrow from 35 RA patients were analysed for CMV (cytomegalovirus, a member of the herpes virus family), EBV (Epstein-Barr), HSV-1, HSV-2 (herpes simplex viruses), parvovirus B19 and polyomavirus using real-time PCR before and 3 months after rituximab (RTX) treatment and related to the levels of autoantibodies and B-cell depletion. [PCR – polymerase chain reaction – is a technique used to identify the presence of disease-causing viruses and/or bacteria.]

Clinical response to RTX was defined as decrease in the 28-joint disease activity score (DAS-28) of more than 1.3 at 6 months.

Results:

Before RTX treatment:

• EBV was identified in 15 out of 35 patients (EBV-positive group), of which 4 expressed parvovirus.

• Parvovirus was further detected in eight patients (parvo-positive group).

• Twelve patients were negative for the analysed viruses.

Following RTX:

• EBV was cleared, whereas parvovirus was unaffected.

• Eighteen patients were responders, of which 12 were EBV positive.

• The decrease in the DAS-28 was significantly higher in EBV-positive group compared with parvo-positive group (P = 0.002) and virus-negative patients (P = 0.04).

• Most of EBV-negative patients that responded to RTX (75%) required retreatment within the following 11 months compared with only 8% of responding EBV-positive patients.

• A decrease of RF, Ig-producing cells and CD19(+) B cells was observed following RTX but did not distinguish between viral infections.

• However, EBV-infected patients had significantly higher levels of Fas-expressing B cells at baseline as compared with EBV-negative groups.

Conclusions:

EBV and parvovirus genomes are frequently found in bone marrow of RA patients.

The presence of EBV genome was associated with a better clinical response to RTX.

Thus, presence of EBV genome may predict clinical response to RTX.

Source: Rheumatology, Jun 14, 2010. Magnusson M, Brisslert M, Zendjanchi K, Lindh M, Bokarewa MI. Department of Rheumatology and Inflammation Research and Department of Virology, Sahlgrenska University Hospital, Göteborg, Sweden.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map