ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

How Lipoic Acid Preserves Critical Mitochondrial Function

Living Longer, Healthier Lives with Resveratrol

Iodine: The Forgotten Medicine

Stop Bacteria With Nature's Antibiotics

Lipoic Acid Reverses Mitochondrial Decay

Nutraceutical Update - Rhodiola

Strengthen Cell Function with Energy-Boosting Niagen

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

 
Print Page
Email Article

A mouse virus, XMRV, closely related to porcine endogenous retroviruses in the human population – A new risk for xenotransplanation? – Source: Xenotransplanation, Feb 22, 2011

  [ 5 votes ]   [ Discuss This Article ]
By J Denner • www.ProHealth.com • April 6, 2011


[Note: Xenotransplantation is the transplantation of living cells, tissues or organs from one species to another – most frequently in current medical practice, from pigs to humans. A transplant of human to human would be an allotransplant.]

There is a need to carefully consider the potential infectious risks associated with xenotransplantation.

Whereas known viruses can easily be eliminated from donor pigs by designated pathogen free breeding of the animals, this is not possible for porcine endogenous retroviruses (PERVs) integrated into the genome of all pigs and unknown viruses.

PERVs infect human cells in vitro [in laboratory cultures] and may theoretically - like many retroviruses - induce immunodeficiencies and/or tumors.

Recently a xenotropic murine leukemia virus related virus (XMRV), a gammaretrovirus that is closely related to murine leukemia viruses as well as to PERV, has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.

Whereas several studies showed a broad distribution of XMRV in the USA, similar studies in Europe failed to detect this virus in the human population (for review see 1). [Note: This does not appear to consider positive European studies.] These results clearly indicate that XMRV is not causally associated with prostate carcinoma and CFS.

Either the virus is common in the USA (may be there are specific populations of rodents releasing this virus) and not in Europe, or it is a laboratory contamination.

If XMRV is indeed circulating in the human population, it has important implications for xenotransplantation.

A test should be developed to discriminate between PERV and XMRV and the potential for recombination between the two viruses should be investigated.

Recombination between the human tropic PERV-A and the ecotropic PERV-C has been described and recombinant PERV-A/C was characterized by increased replication titers.

Whether XMRV and PERV recombine remains unclear, however co-packaging and pseudotyping between PERV and murine retroviruses have been described.

This raises new questions:

• Should the xenotransplant recipient be pre-screened for XMRV to avoid recombination?

• What measures can be taken when XMRV infection is detected in such a screen?

However, before dealing with these specific details, it is necessary to address the important broad questions concerning the distribution of XMRV and its impact on human health.

1. Reference: Denner J. Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation. Retrovirology 2010; 7: 16.

Source: Xenotransplanation, Feb 22, 2011;18(1). From Berlin Symposium on Xenotransplantation. Denner J, Robert Koch Institute, Berlin, Germany.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing