ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Reverse Mitochondrial Damage

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

CoQ10: The Longevity Factor

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

Higher vitamin E intake linked with lower blood pressure

 
Print Page
Email Article

Mass General in Boston Recruiting for Phase I Trial to Reverse Type 1 Diabetes

  [ Not Yet Rated ]   [ Discuss This Article ]
By Massachusetts General Hospital • www.ProHealth.com • March 13, 2008


Mar 13, BOSTON, Mass – Scientists at the Massachusetts General Hospital (MGH) in Boston have initiated a phase I clinical trial to reverse type 1 diabetes. The trial is exploring whether the promising results from the laboratory of Denise Faustman, MD, PhD, can be applied in human diabetes. [For details of the trial and links to the study coordinators, see the listing for Trial # NCT00607230 at ClinicalTrials.gov.]

The Trial Will Involve Tuberculosis Vaccine

Faustman’s previous studies have shown that mice with a form of diabetes that closely resembles type 1 diabetes in humans can be cured. In the animal studies, a commonly used vaccine that provides protection against tuberculosis, called Bacillus Calmette-Guerin (BCG) was used effectively to deplete the abnormal immune cells that attack and destroy the insulin producing cells of the pancreas.

The first step in the human study, which is currently enrolling volunteers, is to determine whether the same strategy using BCG vaccination can be used to modify the abnormal autoimmune cells that are present in type 1 diabetes, sometimes called “juvenile-onset” diabetes.

“We are pleased to be starting human clinical trials,” said Faustman. “Human trials take time, but we are making the step from curing diabetes in mice to determining whether it will work in men and women with diabetes.”

Type 1 diabetes usually starts during childhood or adolescence and can cause a variety of severe complications including kidney failure, loss of vision, amputations, heart disease, and strokes. It occurs when a person’s immune system attacks and destroys the insulin-producing cells in the pancreas. In the absence of insulin, which is necessary for sugar and other nutrients to enter cells, blood sugar levels rise. The risk for developing complications is closely linked to the elevated blood sugar levels over time. If blood sugar levels are well controlled, the long-term complications can largely be avoided.

However, the so-called intensive therapy that is required to maintain near-normal sugar levels requires life-long demands on the patient, including frequent blood sugar monitoring and at least 3 daily injections of insulin or use of an insulin pump, along with restrictive diets. Insulin doses must be adjusted based on blood sugar levels, dietary factors, and anticipated exercise. Thus, a cure for diabetes has been highly sought after and has attracted much research interest.

The clinical trial is using the BCG vaccine for several reasons:

  • BCG has been used safely for nearly 80 years as a tuberculosis vaccine.
  • It is now being used in the human trial because it causes a low-grade inflammatory reaction, which in the mouse model of autoimmune diabetes led to the destruction of the abnormal autoimmune cells.
  • First Step In Potentially Long Process

    David M. Nathan, MD, director of the MGH Diabetes Center, who is leading the human study at MGH, provides context, “This is the very first step in what is likely to be a long process in achieving a cure. We first need to determine whether the abnormal autoimmune cells that underlie type 1 diabetes can be knocked out with BCG vaccination, as occurred in the mouse studies.”

    * * * *

    The Phase I trial is being supported largely through direct and fundraising support from the Iacocca Foundation, and through support from other donors and the Massachusetts General Hospital. The Iacocca Foundation was founded by Lee Iacocca and his family in 1984 to fund innovative approaches to a potential cure for diabetes. Trial information is available to the public at http://www.faustmanlab.org.




    Please Discuss This Article:   Post a Comment 



    [ Be the first to comment on this article ]




     
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Newsletter
    Subscribe Now!
    Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
     Privacy Guaranteed  |  View Archives

    Save on Vitamins and Supplements

    Featured Products

    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    FibroSleep™ by ProHealth FibroSleep™ by ProHealth
    The All-in-One Natural Sleep Aid
    Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
    50,000 IU Vitamin D3 - Prescription Strength
    Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
    Supports Cognition, Memory & Overall Health

    Natural Remedies

    Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
    The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
    The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
    Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
    Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage

    FIBROMYALGIA RESOURCES
    What is Fibromyalgia?
    Fibromyalgia 101
    Fibromyalgia Symptoms
    Fibromyalgia Treatments
    | CFS RESOURCES
    What is CFS?
    ME/CFS 101
    ME/CFS Symptoms
    ME/CFS Treatments
    | FORUMS
    Fibromyalgia
    ME/CFS
    ADVANCED MEDICAL LABS
    WHOLESALE  |  AFFILIATES
    GUARANTEE
    CONTACT US
    PRIVACY
    RSS
    SITE MAP
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing