Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY RESULTS: Medical Marijuana

Decreased levels of vitamin D associated with reduced methylation in African American teens

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

8 Hacks to Slash Medication Costs

Relief from Common Digestive Distress

New Study Shows Optimized Curcumin Stops Inflammation

Block The Vascular Origins Of Cognitive Decline

Selenium - What Is it and Where Do I Get It?

Curcumin: Your Secret Weapon to Speed Muscle Recovery After Intense Exercise

 
Print Page
Email Article

Harvard EEG tests distinguish CFS from major depression patients; temporal lobe implicated

  [ 18 votes ]   [ 1 Comment ]
www.ProHealth.com • July 1, 2011


Article:
EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients - A case control study – Source: BMC (BioMed Central) Neurology, July 1, 2011

By Frank H Duffy, Anthony L Komaroff, et al.

[Note: the full text of this groundbreaking article is available here: http://www.biomedcentral.com/content/pdf/1471-2377-11-82.pdf. This report suggests that distinctive brain activity data may be used to help diagnose and/or differentiate CFS from depression, but further study is needed.]

Abstract:
Background: Previous studies suggest central nervous system involvement in chronic fatigue syndrome (CFS [ME/CFS]), yet there are no established diagnostic criteria. CFS may be difficult to differentiate from clinical depression.

The study’s objective was to determine if spectral coherence, a computational derivative of spectral analysis of the electroencephalogram (EEG), could distinguish patients with CFS from healthy control subjects and not erroneously classify depressed patients as having CFS.

Methods: This is a study, conducted in an academic medical center electroencephalography laboratory, of 632 subjects: 390 healthy normal controls, 70 patients with carefully defined CFS, 24 with major depression, and 148 with general fatigue.

Aside from fatigue, all patients were medically healthy by history and examination. EEGs were obtained and spectral coherences calculated after extensive artifact removal. Principal Components Analysis identified coherence factors and corresponding factor loading patterns.

Discriminant analysis determined whether spectral coherence factors could reliably discriminate CFS patients from healthy control subjects without misclassifying depression as CFS.

Results: Analysis of EEG coherence data from a large sample (n=632) of patients and healthy controls identified 40 factors explaining 55.6% total variance. Factors showed highly significant group differentiation (p<.0004) identifying:

• 89.5% of unmedicated female CFS patients

• And 92.4% of healthy female controls.

Recursive jackknifing showed predictions were stable.

A conservative 10-factor discriminant function model was subsequently applied, and also showed highly significant group discrimination (p<.001), accurately classifying;

• 88.9% unmedicated males with CFS,

• And 82.4% unmedicated male healthy controls.

No patient with depression was classified as having CFS.

The model was less accurate (73.9%) in identifying CFS patients taking psychoactive medications.

Factors involving the temporal lobes were of primary importance.

Conclusions: EEG spectral coherence analysis identified unmedicated patients with CFS and healthy control subjects without misclassifying depressed patients as CFS, providing evidence that CFS patients demonstrate brain physiology that is not observed in healthy normals or patients with major depression.

Studies of new CFS patients and comparison groups are required to determine the possible clinical utility of this test.

The results concur with other studies finding neurological abnormalities in CFS, and implicate temporal lobe involvement in CFS pathophysiology.

Source: BMC (BioMed Central) Neurology, July 1, 2011. doi:10.1186/1471-2377-11-82, by Duffy FH, McAnulty GB, McCreary MC, Cuchural GJ, Komaroff AJ. Departments of Neurology, Psychiatry, Children’s Hospital Boston & Harvard Medical School; Department of Medicine, Brigham & Women’s Hospital & Harvard Medical School; Department of medicine, Tufts Medical Center, Boston, Massachusetts. [Email: Anthony_komaroff@hms.harvard.edu]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

CFS studies vs. depressed patients
Posted by: earthdog2000
Jul 3, 2011
I had a litle trouble understanding this study due to fibrofog. It sounded like it discounted depression from CFS patients and read as if depressed patients did not have CFS if I am correct. I was also surprised that only males were included in this study! why not females since they have a higher rate of CFS and depression?
Reply Reply
 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
"It's Not Easy Being Green" - But It Is Healthy
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map