ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Up-regulation of TGF-beta1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome - Source: Journal of the Formosan Medical Association, Nov 2011

  [ 20 votes ]   [ Discuss This Article ]
By HY Zhang, et al. • www.ProHealth.com • December 1, 2011


[Note: TGF-beta1 stands for “transforming growth factor beta” type 1. It is a protein secreted by most immune cells (leukocytes) and plays an important role in controlling the immune system. Its effect differs depending on the type of cell involved, and at different cellular developmental stages (e.g.,  growth, multiplication, differentiation, cell death).]

Background/Purpose: It has been shown that the abnormality in immune cells in chronic fatigue syndrome (CFS) patients is closely associated with the participation of TGF-beta.

In order to study the relationship between TGF-beta1 and CFS, we investigated the mRNA levels of TGF-beta1 in peripheral blood mononuclear cells (PBMCs) in patients with CFS.

Methods: Fluorescent quantitative real time reverse-transcription polymerase chain reaction (FQ-RT-PCR) was performed to test TGF-beta1 mRNA expression in PBMCs in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.

Results: The mean value of TGF-beta1 mRNA expression in CFS patients was deltadeltaCt=1.17±0.58, which was significantly higher than the disease controls (deltadeltaCt=0.07±1.08, df=111, p < 0.01) and the healthy controls (deltadeltaCt=0.00±1.63, df=111, p < 0.01). No significant difference was detected between disease and healthy controls (p > 0.05).

Conclusion: The expression of TGF-beta1 in peripheral blood mononuclear cells is significantly elevated in patients with CFS. It might be correlated to the pathogenesis of the disease.

Source: Journal of the Formosan Medical Association, Nov 2011;110(11):701-4. PMID:22118314, by Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map