ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Both key papers on CFS retroviral involvement retracted, but Lipkin’s virus hunt proceeds

  [ 9 votes ]   [ Post a Comment ]
www.ProHealth.com • December 27, 2011

previous article next article

A multi-center research team is now searching for evidence of murine gamma retroviruses or other viral involvement in 150 well-defined, geographically diverse chronic fatigue syndrome patient samples. The study, led by Columbia University’s “virus hunter,” Ian Lipkin, and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) expects to have results some time in 2012.

As Dr. Lipkin has suggested, CFS “smells like a viral disease,” and his lab will be using “next generation” genetic sequencing in the CFS study. (According to him, this technology has allowed identification of 500 new viruses so far.)

Meanwhile, Both the Lo-Alter and Mikovits Papers Have Been Retracted

On December 27, a paper by Shyh-Ching Lo, Harvey Alter, et al. (the Lo, Alter paper), published in August 2010 by the Proceedings of the National Academy of Sciences,(1) has been retracted by the authors. Their paper reported finding human MLV-like retroviruses (members of the XMRV family) in 32 of 37 Chronic Fatigue Syndrome patients and 3 of 44 healthy blood donors.

All the authors signed the retraction statement, noting that their findings have not withstood the test of independent verification. (Still, they also note that they have found no evidence of contamination in their testing materials – and though they believe their previous findings could be reproduced in their own labs, at this point they don’t have enough “original CFS patient samples to do additional testing.”)

This follows news of the December 22 “editorial retraction” by the journal Science of the original October 2009 paper by Mikovits et al., which reported evidence of  XMRV in the blood of many CFS patients and some healthy controls.(2) The editors base their retraction on failure of subsequent studies in other labs to find XMRV in CFS patient samples, and the discovery by two authors of the Science report (at the Cleveland Clinic) of contaminants in materials/samples they used.

Expert Opinions Differ on the Contamination Question

On December 20, Wall Street Journal ME/CFS-tracker Amy Dockser-Marcus reported comments by a number of experts demonstrating that the issue of contamination is far from resolved ("XMRV: Raising the Issue of Contamination"). Tests used to detect XMRV can also detect mouse DNA, and mouse DNA is everywhere in labs. But past studies of XMRV in prostate cancer have found it integrated into patient DNA - and thus hard to explain as contamination.

_____

1. “Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors.”

2. “Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.”
 


previous article
  Rating 3.4 (9 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing