Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Social Anxiety Disorder Linked to High Serotonin Levels, Throwing Treatment with SSRIs into Serious ...

A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream surviva...

Therapeutic Effects and Mechanisms of Action of Rifaximin in Gastrointestinal Diseases

Promoting Optimal Nutrition with Digestive Enzymes

Immune response to a flu vaccine yields new insights into narcolepsy

Omega-3 supplements and antioxidants may help with preclinical Alzheimer's disease

Children with Lyme Disease

Health Benefits of Ginseng

7-Keto DHEA The Fat-Burning Metabolite of DHEA

Intestinal Pseudoobstruction Caused by Chronic Lyme Neuroborreliosis. A Case Report

 
Print Page
Email Article

Researchers watch omega-3s at work for first time in living cells

  [ 3 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 15, 2012


Researchers at University of California, San Diego have actually peered inside a living cell and mapped the processes that power the celebrated health benefits of omega-3 fatty acids, according to their report published May 14 by Proceedings of the National Academy of Sciences.(1)

This is the first comprehensive study of what omega-3s actually do inside a cell vis-a-vis inflammation, explains UCSD lipid lab director Edward A Dennis, PhD. And it's groundbreaking because it provides important insights into how inflammatory activity might be manipulated.

Benefits were Seen But Not Understood

The therapeutic benefits of omega-3 fatty acids, which are abundant in certain fish oils, have been known at least since the 1950s when cod liver oil was found to be beneficial for people with ailments like eczema and arthritis.

In the 1980s, scientists reported that Eskimos eating a fish-rich diet enjoyed better coronary health than counterparts consuming a “western” diet.

And since then "there have been tons of epidemiological studies linking health benefits to omega-3 oils… but not a lot of deep science," says Dr. Dennis.

The Study

Dr. Dennis and co-author Paul C. Norris, a graduate student, fed three different kinds of fatty acid to mouse macrophages - a type of white blood cell: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA).

• EPA and DHA are major polyunsaturated omega-3 fatty acids, essential to a broad range of cellular and bodily functions, and the primary ingredient in commercial fish oil dietary supplements.

• AA is a polyunsaturated omega-6 fatty acid that is prevalent in the human diet, in foods such as meat, seafood and eggs.

Able to Support Inflammatory Response When Needed

In high levels, fatty acids are toxic, so cells typically sequester them as phospholipids in their membranes. When stimulated, however, the fatty acids may be released, provoking a cascading inflammatory response.

• Acute or limited inflammation is, of course, a vital immunological response to physical damage or invasive pathogens.

• But chronic inflammation is harmful and a common element of almost every disease, from diabetes to cancer.

After supplementing the mouse macrophages with fatty acids, the scientists stimulated them to produce an inflammatory response.

• They discovered that omega-3 fatty acids inhibit an enzyme called cyclooxygenase (COX), which produces the prostaglandin hormones that spark inflammation.

• The action is similar to what happens when one takes an aspirin, which disrupts the COX-2 signaling pathway (as a so-called COX-2 inhibitor), thus reducing inflammation and pain.

On the other hand, they discovered that omega-3 oils do not inhibit another group of enzymes called lipoxygenases (LOX), which are also produced by stimulated macrophages.

• One type of generated LOX enzyme in turn produces fat-signaling molecules called leukotrienes, which are pro-inflammatory.

• But, Norris notes, the LOX enzymes may also generate anti-inflammatory compounds called resolvins from EPA and DHA.

These observations, he said, are also helpful in identifying potential adverse effects from taking fish oil.

• Since omega-3 fatty acids possess overlapping functions with COX inhibitor drugs, with well-known side effects, using both in combination can produce unexpected consequences.

• It is this parsing of what's happening inside cells that Dr. Dennis has called "ground-breaking."

"Now,” he says, “we need to learn if we can fine-tune that process so we can use omega-3 oils to:

• Reduce the production of pro-inflammatory prostaglandins

• And boost the production of anti-inflammatory resolvins.”

______

1. Article: “Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling,” PNAS, May 14, 2012, by Paul C Norris and Edward A Dennis.

Source: Based on University of California - San Diego press release, May 15, 2012



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Live Without Anxiety or Stress

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing