Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY RESULTS: Medical Marijuana

Decreased levels of vitamin D associated with reduced methylation in African American teens

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

8 Hacks to Slash Medication Costs

New Study Shows Optimized Curcumin Stops Inflammation

Relief from Common Digestive Distress

Block The Vascular Origins Of Cognitive Decline

Curcumin: Your Secret Weapon to Speed Muscle Recovery After Intense Exercise

7 Natural Ways to Prevent Diabetes

 
Print Page
Email Article

New Hope for Neuropathic Pain: Drug Keeps Nerve-Calming Potassium Channels Open

  [ 37 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 23, 2012


New medication, already licensed & headed for clinical trials, "could bring relief to hundreds of millions."

Neuropathic pain (aka nerve pain or neuropathy) involves impulses from damaged, sensitive nerve fibers which are felt, for example, as tingling, burning, or stabbing sensations. Nerve pain often becomes chronic and can be disabling, and commonly develops in diabetes, lupus, shingles, complex regional pain syndromes, sciatica, phantom limb pain, MS, Parkinson's, post-stroke pain, and more.

Nerve pain is hard to alleviate with commonly used over-the-counter analgesics such as paracetamol or ibuprofen, or even morphine.

But a drug developed at Tel Aviv University – dubbed BL 7050 – offers new hope for people suffering with neuropathic pain.

According to the developers, Drs. Bernard Attali and Asher Peretz, working in the Sackler School of Medicine's Attali lab:

• BL 7050, delivered in pill form, has been demonstrated in pre-clinical animal trials to efficiently inhibit transmission of pain signals and epileptic seizures as well. It does this by avoiding nerve fiber hyperexcitement. While on the medication, rats experiencing both epilepsy and neuropathic pain were no longer affected by stimuli that had previously caused pain. Measures in the electrical activities of neurons also revealed that the medication was able to induce "calm" in the neurons, inhibiting pain pathways.

• BL 7050 has already been licensed for development & commercialization via Tel Aviv University’s technology transfer arm.

• And will move to clinical trials in humans “in the near future.”

The Quest to Stabilize Cellular Potassium Channels

As the researchers have reported in the journal PNAS as their work progressed, the medication works by targeting a group of proteins which act as channels or ‘pores’ in membranes of cells – allowing potassium to flow readily across the membrane. Understanding the  the mechanism that controls these potassium channels was crucial to development of the drug.

• Potassium has a crucial role in the excitability of cells, specifically those in the nervous system and the heart.

• When potassium channels don't function properly, cells are prone to hyper-excitability, leading to neurological and cardiovascular disorders such as epilepsy and arrhythmias.

• These are also the channels that convey pain signals caused by nerve or tissue damage, known as neuropathic pain.

• The researchers set out to develop a medication that could bind to and stabilize the body's potassium channels, controlling their hyper-excitability and preventing the occurrence of pain by keeping the channels open for the outflow of potassium.

• And, subject to upcoming phase one clinical trials, BL 7050 so far appears to fit the bill.

Source: Adapted from Friends of Tel Aviv University Press Release, Apr 30, 2012




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map