ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

The Fast-Acting Solution for Healthy Digestive Function

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

Higher vitamin E intake linked with lower blood pressure

 
Print Page
Email Article

New Hope for Neuropathic Pain: Drug Keeps Nerve-Calming Potassium Channels Open

  [ 36 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 23, 2012


New medication, already licensed & headed for clinical trials, "could bring relief to hundreds of millions."

Neuropathic pain (aka nerve pain or neuropathy) involves impulses from damaged, sensitive nerve fibers which are felt, for example, as tingling, burning, or stabbing sensations. Nerve pain often becomes chronic and can be disabling, and commonly develops in diabetes, lupus, shingles, complex regional pain syndromes, sciatica, phantom limb pain, MS, Parkinson's, post-stroke pain, and more.

Nerve pain is hard to alleviate with commonly used over-the-counter analgesics such as paracetamol or ibuprofen, or even morphine.

But a drug developed at Tel Aviv University – dubbed BL 7050 – offers new hope for people suffering with neuropathic pain.

According to the developers, Drs. Bernard Attali and Asher Peretz, working in the Sackler School of Medicine's Attali lab:

• BL 7050, delivered in pill form, has been demonstrated in pre-clinical animal trials to efficiently inhibit transmission of pain signals and epileptic seizures as well. It does this by avoiding nerve fiber hyperexcitement. While on the medication, rats experiencing both epilepsy and neuropathic pain were no longer affected by stimuli that had previously caused pain. Measures in the electrical activities of neurons also revealed that the medication was able to induce "calm" in the neurons, inhibiting pain pathways.

• BL 7050 has already been licensed for development & commercialization via Tel Aviv University’s technology transfer arm.

• And will move to clinical trials in humans “in the near future.”

The Quest to Stabilize Cellular Potassium Channels

As the researchers have reported in the journal PNAS as their work progressed, the medication works by targeting a group of proteins which act as channels or ‘pores’ in membranes of cells – allowing potassium to flow readily across the membrane. Understanding the  the mechanism that controls these potassium channels was crucial to development of the drug.

• Potassium has a crucial role in the excitability of cells, specifically those in the nervous system and the heart.

• When potassium channels don't function properly, cells are prone to hyper-excitability, leading to neurological and cardiovascular disorders such as epilepsy and arrhythmias.

• These are also the channels that convey pain signals caused by nerve or tissue damage, known as neuropathic pain.

• The researchers set out to develop a medication that could bind to and stabilize the body's potassium channels, controlling their hyper-excitability and preventing the occurrence of pain by keeping the channels open for the outflow of potassium.

• And, subject to upcoming phase one clinical trials, BL 7050 so far appears to fit the bill.

Source: Adapted from Friends of Tel Aviv University Press Release, Apr 30, 2012



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
"It's Not Easy Being Green" - But It Is Healthy
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing