Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

12 Celebrities with Lyme Disease

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

How Essential Oils Can Help Improve Your Life

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Clinically Studied Joint Relief Product for FM & ME/CFS

Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteoli...

 
Print Page
Email Article

Scientists Find That Interferons Induce Persistent Viral Infection

  [ 6 votes ]   [ 1 Comment ]
www.ProHealth.com • April 19, 2013


Editor's Comment: Type I interferons, also known as alpha and beta interferon, are upregulated during viral infections. It has long been thought that Type I interferons are powerful antiviral agents. However, this study reveals that Type I interferons actually perpetuate chronic viral infections by suppressing effective antiviral immune reponses. By blocking Type I interferons, the researchers found that although circulating virus was higher for the first few days of infection, it was cleared much faster, preventing the infection from becoming chronic. Dr. Paul Cheney observed many years ago that patients with CFS have high levels of alpha interferon. For a more in-depth discussion of this significant finding, please read the article in Science Daily.

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

By John R. Teijaro et al.

Abstract

During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. IFN-I blockade before and after establishment of persistent virus infection resulted in enhanced virus clearance and was CD4 T cell–dependent. Hence, we demonstrate a direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence. Our results suggest that therapies targeting IFN-I may help control persistent virus infections.

Source: Science 12 April 2013: Vol. 340 no. 6129 pp. 207-211 DOI: 10.1126/science.1235214. John R. Teijaro1, Cherie Ng, Andrew M. Lee, Brian M. Sullivan, Kathleen C. F. Sheehan, Megan Welch, Robert D. Schreiber, Juan Carlos de la Torre, Michael B. A. Oldstone




Please Discuss This Article:   Post a Comment 

In addition
Posted by: IanH
Apr 19, 2013
Compounding this is the Type II IFN, IFN-gamma.
IFN-gamma potentiates the type-I interferons but when it is persistently elevated itself it depolarizes the mitochondrial membrane causing energetics problems of the sort we see in many neuro-immune diseases, autism and ME/CFS included.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Safely Burn Away Body Fat Safely Burn Away Body Fat
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing