ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

Print Page
Email Article

Chronic Fatigue Syndrome Researcher Turns Pilot Study into Major Grant

  [ 14 votes ]   [ 1 Comment ]
By Cort Johnson • • January 9, 2015

Chronic Fatigue Syndrome Researcher Turns Pilot Study into Major Grant
Reprinted with the kind permission of Cort Johnson and Health Rising

By Cort Johnson

Patrick McGowan’s  epigenetic research started out as a small 24 person pilot project funded by the SolveCFS Initiative but it’s not small any more. With the help of a $500,000 grant from the Dr. Ralph and Marian Falk Medical Research Trust, Patrick McGowan (and Dr. Lucinda Bateman) are now embarking on a 300 person study.

Epigenetics studies changes how our genes express themselves over time in. Think of your genetic makeup as a blank slate when you were born. Look forward twenty or thirty years, though, and you’ll see portions of that slate have been over-written: some genes that weren’t turned on back then are now turned on. Others that were going full bore have been silenced.  That’s epigenetics – a field some researchers believe may, in the end, be ultimately more important with regard to chronic diseases than our original genetic makeup.

Consider the possibility that key genes that were serving to keep you strong and healthy got turned off or possibly genes that were guaranteed to make you sick got turned on just before you became ill. Maybe it wasn’t that bug, that flu or whatever you thought it was that got you ill. Maybe the problem was that your gene expression changed. If that’s true then good luck trying to fix the problem without getting at those epigenetic changes. Everything you do will be like a bandaid put over a genetic sore.

McGowan’s SolveCFS Initiative pilot study found epigenetic changes in 800 genes involved in metabolic  regulation (energy production), kinase activities (metabolic  and much more), the immune response and more in people with ME/CFS.  His finding appeared to be on track with what we know: they suggested ME/CFS patients immune systems were skewed to a Th2 immune response and they highlighted inflammatory processes.  One particularly interesting epigenetically altered gene was associated with EBV infection of B-cells. Another effected a major inflammatory transcription factor called NF-kB which turns on genes involved in inflammation.

The Dr. Ralph and Marian Falk Medical Research Trust obviously felt McGowan was on to something because they awarded him one of ten  or so grants they are giving out  in their new translational research effort that opened in October.  This effort emphasized these factors:
  • Understanding underlying disease processes and how they disrupt normal human biology,

  • Identification of biological markers of disease activity and progression

  • Development and testing of diagnostic or prognostic tests based on those markers

McGowan’s research could affect all three: understanding ME/CFS, finding  biomarkers and developing diagnostic tests.

This grant shows once again that pilot studies work, and that more and more funders are considering ME/CFS a  subject  they want to invest in. The  Dr. Ralph and Marian Falk Medical Research Trust is not a flash in the pan; it’s  an established non-profit that’s given out almost $200 million in grants over the past thirty years.

It’s good news when a long-established funder believes chronic fatigue syndrome is a good investment. The competition in this era of reduced NIH budgets was probably fierce. Kudo’s to whoever took advantage of this funding opportunity.

About the Author: Cort Johnson has had ME/CFS for over 30 years. The founder of Phoenix Rising and Health Rising, Cort has contributed hundreds of blogs on chronic fatigue syndrome, fibromyalgia and their allied disorders over the past 10 years. Find more of Cort's and other bloggers' work at Health Rising.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Article Comments Post a Comment

Half million awarded to SMCI
Posted by: LAReynolds
Jan 9, 2015
Cort, thanks again for a great write up. In fact, Dr Vernon wrote the proposal to the Falk Medical Trust and the award was given to the Solve ME/CFS Initiative. ( SMCI will contract with Dr’s McGowan and Bateman to collaboratively expand this study and SMCI/Dr. Vernon will manage the program. It is a very exciting, worthwhile and important study and SMCI is thrilled to have received the award to further explore this important area.
Reply Reply
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map