ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Why So Many Arthritis Sufferers Fail to Find Relief

Discovering Coffee's Unique Health Benefits

Safely Manage Joint Inflammation: Curcumin

Bay Area Lyme Foundation Awards Grant to Harvard Medical School Researchers for Development of an Ac...

Therapeutic program reverses cognitive decline

 
Print Page
Email Article

Novel Painkiller has Positive Phase II Clinical Results

  [ 245 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 8, 2001



The drug development company, Pain Therapeutics, Inc., recently announced positive results from preliminary analysis of a large Phase II clinical trial with the drug PTI-555. PTI-555 is an investigational painkiller proposed as a substitute for morphine and similar narcotic painkillers.

This Phase II trial was a multi-center, randomized, double blind, placebo and active controlled human clinical trial comparing PTI-555 to morphine sulfate, and placebo.

The trial enrolled 210 patients with moderate to severe pain following major oral surgery significant enough to warrant opioid analgesia. Immediately after surgery, patients were randomly assigned to receive a single oral nominal dose of PTI-555, morphine sulfate, or placebo.

PTI-555 is a combination of morphine sulfate and low-dose naltrexone. The primary efficacy endpoint in this trial was pain relief within eight hours of dosing.

Patients given a single oral dose of PTI-555 90mg achieved significantly more total pain relief over four hours compared to patients given a single 90mg dose of oral morphine sulfate with no significant change in the incidence of side effects. In addition, patients given a single oral dose of PTI-555 90mg achieved significantly more total pain relief over four hours compared to patients given placebo.

Twenty-five percent of patients given a single oral dose of PTI-555 90mg achieved complete pain relief within eight hours of dosing, compared to just three percent of patients given a single 90mg dose of oral morphine sulfate.

PTI-555 was well tolerated and was not associated with any reported serious adverse events, either during the trial or the subsequent follow-up period. The percentage of patients reporting any drug related adverse events during the 24 hours following dosing was approximately the same in the two drug groups. Certain nervous system conditions, such as somnolence, fatigue, and euphoria, occurred less frequently in the PTI-555 treatment group.

"These positive results are an important clinical milestone for our initiative to develop a drug that's better than morphine," said Barry Sherman, M.D., executive vice president and chief medical officer of Pain Therapeutics, Inc. "The novel pharmacological theory that low doses of opioid antagonist can improve the performance of opioid agonists, such as morphine, continues to be supported in large numbers of patients."







Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing