ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

7 Best Foods You Can Eat

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Controlling obesity with potato extract

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

 
Print Page
Email Article

Abstract: Treatment of Fibromyalgia with Antidepressants: A Meta-Analysis

  [ 46 votes ]   [ Discuss This Article ]
By P.G. O'Malley, E. Balden, G. Tomkins, J. Santoro, K. Kroenke, J.L. Jackson • www.ProHealth.com • November 7, 2001



Competing interests: None declared

Funding: MacArthur Foundation Initiative on Depression in Primary Care. This digest and commentary appeared in Evidence-Based Medicine, 2001; 6:77

DATA SOURCES
Studies in any language were identified by searching MEDLINE (1966 to June 1999), PsycLIT (1974-1998), and EMBASE/Excerpta Medica (1974-1998) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.

STUDY SELECTION
Studies were selected if they were randomized, placebo-controlled trials with at least 1 group receiving an antidepressant drug and if they reported measurable outcomes.

DATA EXTRACTION
Data were extracted on setting; country; dose, duration, and follow-up of treatment; number of participants and demographics; assessment of comorbid disease; follow-up losses (i.e., unavailable for follow-up); adverse effects; and outcomes. Methodologic quality of individual trials was assessed using the Jadad scale.

MAIN RESULTS
We included 13 trials (mean sample size, 54; mean duration, 8.1 weeks) in the analysis. Mean quality score for the Jadad scale was 5.6 of a maximum of 8. Nine studies did not give the method of randomization, 7 had no intention-to-treat analysis, 3 inadequately assured blinding effectiveness, 5 did not assess adverse effects, and 6 had lower than 20% loss to follow-up. Trials assessed the efficacy of 3 classes of antidepressant drugs: tricyclic antidepressants (8 trials of amitriptyline hydrochloride, 1 of clomipramine hydrochloride, and 1 of maprotiline hydrochloride), S-adenosyl-1-methionine (2 trials), and selective serotonin reuptake inhibitors (2 of fluoxetine hydrochloride and 1 of citalopram hydrobromide).

Meta-analysis was done using a random-effects model. Meta-analysis of dichotomous outcome data (10 trials) showed that patients who received antidepressants had more symptom improvement than those who received placebo (odds ratio, 4.2 [95% confidence interval (CI), 2.6-6.8]; number needed to treat, 4 [95% CI, 2.9-6.3]). Meta-analysis of continuous outcome data showed that antidepressant drugs were associated with improvements in fatigue scores (8 trials, 0.39 SD unit improvement [95% CI, 0.11-0.66]), sleep scores (8 trials, 0.49 SD unit improvement [95% CI, 0.3-0.69]), pain scores (10 trials, 0.52 SD unit improvement [95% CI, 0.21-0.81]), and overall well-being (7 trials, 0.49 SD unit improvement [95% CI, 0.18-0.80]) but not in the number of trigger points.

CONCLUSION
Antidepressant drugs improve overall symptoms and individual symptoms of fatigue, sleep, and pain in patients with fibromyalgia.











Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing