ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

CoQ10: The Longevity Factor

Magnesium: Widespread Deficiency with Deadly Consequences

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

Is Homocysteine Making You Sick?

Extending Life and Fighting Disease with Resveratrol

VIDEO: Beautiful Clouds - Relaxation and Meditation

 
Print Page
Email Article

Genes May Enhance Ill Health From Organophosphate Exposure

  [ 14 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 7, 2002




By Harvey McConnell (02/28/2002)

Source: The Lancet


Some farmers appear to have a genetic predisposition to the adverse health effects associated with exposure to organophosphate in sheep dip.

Results of a study by Dr Nicola Cherry and colleagues from the University of Manchester "provide support for those who believe that repeated exposure to organophosphates may cause chronic ill health."

Exposure to organophosphates has acute effects on health, but evidence of chronic effects is unclear. Many people who have been occupationally exposed to these chemicals, especially in sheep farming, think them to be a cause of poor health.

Clinicians explain that human serum paraoxonase (PON1) hydrolyses organophosphates. Isoforms of the enzyme, which differ in their PON1 activity, result from aminoacid substitutions at positions 192 (glutamine to arginine) and 55 (leucine to methionine). The effect of the 192 polymorphism depends upon the substrate; diazinonoxon, the active metabolite of diazinon, an organophosphate often used in sheep dip chemicals in the UK, is hydrolysed more slowly by the R than the Q alloenzyme.

Dr Cherry investigated the relation between genetic variations in the gene regulating paraoxonase and health outcomes in farmers. The researchers recruited 175 farmers who reported ill health attributed to exposure to sheep dip. In turn, the farmers nominated 234 other farmers who also dipped sheep and whom they believed to be in good health.

Researchers calculated the odds ratios for polymorphisms in the gene regulating paraoxonase, and therefore the ability to break down toxic organophosphates. Farmers who reported poor health were nearly twice as likely than the healthy farmers to have specific alterations in the gene regulating paraoxonase.

These farmers were more likely to have at least one R allele at position 192 (glutamine to arginine aminoacid substitution; odds ratio 1.93, 95 percent CI 1.24-3.01), both alleles of type LL (1.70, 1.07-2.68) at position 55, and to have diazoxonase activity below normal median (1.77, 1.18"2.67).

"Our results support the hypothesis that organophosphates contribute to the reported ill health of people who dip sheep, " the researchers said.

Dr Cherry in comments, said: "The study was set up to test a clear hypothesis, that those whose genes produced a less efficient enzyme would, if exposed to organophosphates, be more likely to become ill.

"The results provide support for those who believe that repeated exposure to organophosphates may cause chronic ill health. Sheep dippers in the UK are one important group, but there are many others world-wide who are exposed to these chemicals and whose health may be affected as a result."


Lancet 2002; 359: 763-64.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
"It's Not Easy Being Green" - But It Is Healthy
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing