ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

List of diseases spread by deer tick grows, including malaria-like problems and potentially fatal en...

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Lyme disease confirmed in humans from southern states

Anticancer Properties Of Saffron

Teenager with stroke symptoms actually had Lyme disease

World Famous Joint Relief Formula Enhanced by Modern Science

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from do...

Autistic and non-autistic brain differences isolated for first time

In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges

Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

 
Print Page
Email Article

Growth Hormone Perturbations in Fibromyalgia: A Review

  [ 212 votes ]   [ Discuss This Article ]
By Kim D. Jones, et al • www.ProHealth.com • February 7, 2007


Journal: Seminars in Arthritis and Rheumatism (2007 Jan 12). Published online 16 January 2007.

Authors and affiliation: Kim D. Jones, Parimal Deodhar, Ashley Lorentzen, Robert M. Bennett, Atul A. Deodhar. Oregon Health & Science University School of Nursing and School of Medicine (Division of Arthritis & Rheumatic Diseases), Portland.
[E-Mail: joneskim@ohsu.edu ] PMID: 17224178

Objective: Fibromyalgia (FM) is a syndrome characterized by chronic widespread pain, fatigue, disrupted sleep, depression, and physical deconditioning. In this article, we review the literature on the normal activity of the hypothalamic-pituitary-growth hormone-insulin-like growth factor-1 (HP-GH-IGF-1) axis and its perturbations in FM subjects.

Methods: Studies included in this review were accessed through an English language search of Cochrane Collaboration Reviews. Keyword MeSH terms included “fibromyalgia,” “growth hormone” (GH), or “insulin-like growth factor-1” (IGF-1).

Results: Twenty-six studies enrolling 2006 subjects were reviewed. Overall, low levels of IGF-1 were found in a subgroup of subjects. Growth hormone stimulation tests often revealed a suboptimal response, which did not always correlate with IGF-1 levels. No consistent defects in pituitary function were found. Of the 3 randomized placebo controlled studies, only 9 months of daily injectable recombinant GH reduced FM symptoms and normalized IGF-1.

Conclusions: These studies suggest that pituitary function is normal in Fibromyalgia and that reported changes in the HP-GH-IGF-1 axis are most likely hypothalamic in origin. The therapeutic efficacy of supplemental GH therapy in FM requires further study before any solid recommendations can be made.

Keywords: Fibromyalgia, growth hormone (GH), insulin-like growth factor-1 (IGF-1), somatostatin, growth hormone releasing hormone (GHRH), hypothalamus, pituitary




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Video: Goodnighties Ionized Sleepwear
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing