ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Print Page
Email Article

Growth hormone as concomitant treatment in severe Fibromyalgia associated with low IGF-1 serum levels. A pilot study - Source: BMC Musculoskeletal Disorders, Nov 30, 2007

  [ 108 votes ]   [ 1 Comment ]
By Guillem Cuatrecasas, MD, et al. • • December 8, 2007

[Note: The full text of this article is available free of charge at ]

Background: There is evidence of functional growth hormone (GH) deficiency, expressed by means of low insulin-like growth factor 1 (IGF-1) serum levels, in a subset of fibromyalgia patients. The efficacy of GH versus placebo has been previously suggested in this population. We investigated the efficacy and safety of low dose GH as an adjunct to standard therapy in the treatment of severe, prolonged and well-treated fibromyalgia patients with low IGF-1 levels.

Methods: Twenty-four patients were enrolled in a randomized, open-label, best available care-controlled study. Patients were randomly assigned to receive either 0.0125 mg/kg/d of GH subcutaneously (titrated depending on IGF-1) added to standard therapy or standard therapy alone during one year. The number of tender points, the Fibromyalgia Impact Questionnaire (FIQ) and the EuroQol 5D (EQ-5D), including a Quality of Life visual analogic scale (EQ-VAS) were assessed at different time-points.


  • At the end of the study, the GH group showed a 60% reduction in the mean number of tender points (pairs) compared to the control group (p<0.05; 3.25+/-0.8 vs. 8.25+/-0.9).
  • Similar improvements were observed in FIQ score (p<0.05) and EQ-VAS scale (p<0.001).
  • There was a prompt response to GH administration, with most patients showing improvement within the first months in most of the outcomes.
  • The concomitant administration of GH and standard therapy was well tolerated, and no patients discontinued the study due to adverse events.
  • Conclusions: The present findings indicate the advantage of adding a daily GH dose to the standard therapy in a subset of severe fibromyalgia patients with low IGF-1 serum levels.

    Trial Registration: NCT00497562 (

    Source: BMC Musculoskeletal Disorders. 2007 Nov 30;8(1):119 [E-pub ahead of print] PMID: 18053120, by Cuatrecasas G, Riudavets C, Guell MA, Nadal A. Servicio de Endocrinología, Centro Médico Teknon, Barcelona, Spain. [E-mail: Guillem Cuatrecasas, MD,]

    Post a Comment

    Featured Products From the ProHealth Store
    Ultra EPA  - Fish Oil FibroSleep™ Ultra ATP+, Double Strength

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products

    Article Comments Post a Comment

    Growth Hormone Study
    Posted by: brighteyestish
    Dec 19, 2007
    I was in a 6 month study with a oral growth hormone and It did very well. It took 3-4 months before I started to stop hurting. At the end of the study My tender points not longer hurt...AT ALL. Now that I am off of it I feel sluggish and drained. I hope they put it on the market.
    Reply Reply
    Natural Pain Relief Supplements

    Featured Products

    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid

    Natural Remedies

    Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
    Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
    The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
    Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
    Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    Credit Card Processing
    Be the first to know about new products, special discounts and the latest health news. *New subscribers only

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map