Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

Acupuncture reduces hot flashes in breast cancer survivors

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

SURVEY: Has Your Illness Affected What You Eat?

DePaul Study Recruiting Participants

VIDEO: Dr. Horowitz Discusses Lyme Disease and Chronic Illness

Cocoa flavanols lower blood pressure and increase blood vessel function in healthy people

Detection of Invasive Borrelia burgdorferi Strains in North-Eastern Piedmont, Italy.

Print Page
Email Article

Growth hormone as concomitant treatment in severe Fibromyalgia associated with low IGF-1 serum levels. A pilot study - Source: BMC Musculoskeletal Disorders, Nov 30, 2007

  [ 108 votes ]   [ 1 Comment ]
By Guillem Cuatrecasas, MD, et al. • • December 8, 2007

[Note: The full text of this article is available free of charge at ]

Background: There is evidence of functional growth hormone (GH) deficiency, expressed by means of low insulin-like growth factor 1 (IGF-1) serum levels, in a subset of fibromyalgia patients. The efficacy of GH versus placebo has been previously suggested in this population. We investigated the efficacy and safety of low dose GH as an adjunct to standard therapy in the treatment of severe, prolonged and well-treated fibromyalgia patients with low IGF-1 levels.

Methods: Twenty-four patients were enrolled in a randomized, open-label, best available care-controlled study. Patients were randomly assigned to receive either 0.0125 mg/kg/d of GH subcutaneously (titrated depending on IGF-1) added to standard therapy or standard therapy alone during one year. The number of tender points, the Fibromyalgia Impact Questionnaire (FIQ) and the EuroQol 5D (EQ-5D), including a Quality of Life visual analogic scale (EQ-VAS) were assessed at different time-points.


  • At the end of the study, the GH group showed a 60% reduction in the mean number of tender points (pairs) compared to the control group (p<0.05; 3.25+/-0.8 vs. 8.25+/-0.9).
  • Similar improvements were observed in FIQ score (p<0.05) and EQ-VAS scale (p<0.001).
  • There was a prompt response to GH administration, with most patients showing improvement within the first months in most of the outcomes.
  • The concomitant administration of GH and standard therapy was well tolerated, and no patients discontinued the study due to adverse events.
  • Conclusions: The present findings indicate the advantage of adding a daily GH dose to the standard therapy in a subset of severe fibromyalgia patients with low IGF-1 serum levels.

    Trial Registration: NCT00497562 (

    Source: BMC Musculoskeletal Disorders. 2007 Nov 30;8(1):119 [E-pub ahead of print] PMID: 18053120, by Cuatrecasas G, Riudavets C, Guell MA, Nadal A. Servicio de EndocrinologĂ­a, Centro MĂ©dico Teknon, Barcelona, Spain. [E-mail: Guillem Cuatrecasas, MD,]

    Please Discuss This Article:   Post a Comment 

    Growth Hormone Study
    Posted by: brighteyestish
    Dec 19, 2007
    I was in a 6 month study with a oral growth hormone and It did very well. It took 3-4 months before I started to stop hurting. At the end of the study My tender points not longer hurt...AT ALL. Now that I am off of it I feel sluggish and drained. I hope they put it on the market.
    Reply Reply
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Subscribe Now!
    Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
     Privacy Guaranteed  |  View Archives

    Vitamins and Supplements

    Featured Products

    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid

    Natural Remedies

    Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
    Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
    Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
    Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
    Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

    What is Fibromyalgia?
    Fibromyalgia Diagnosis
    Fibromyalgia Symptoms
    Fibromyalgia Causes
    Fibromyalgia Treatments
    Fibromyalgia Diet
    Fibromyalgia Medications
    M.E. & CFS
    What is M.E./CFS?
    M.E./CFS Diagnosis
    M.E./CFS Symptoms
    M.E./CFS Causes
    M.E./CFS Treatments
    M.E./CFS Diet
    M.E./CFS Medications
    What is Lyme Disease?
    Lyme Disease Diagnosis
    Lyme Disease Symptoms
    Lyme Disease Causes
    Lyme Disease Treatments
    Lyme Disease Diet
    Lyme Disease Medications
    M.E. & CFS
    Lyme Disease
    General Health
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing