Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

SURVEY RESULTS: Has Your Illness Affected What You Eat?

New depression diagnosis and treatment

Surprising Benefits of Cinnamon

Specific vitamin D levels linked to heart problems

A Sleep Intervention For Children With Autism: A Pilot Study

Higher vitamin D levels may be protective against acute rhinosinusitis

Real Life as a Mom with Chronic Illness

Saffron reduces oxidative stress in metabolic syndrome patients

Print Page
Email Article

Genetic evaluation of the serotonergic system in Chronic Fatigue Syndrome – Source: Psychoneuroendocrinology, Dec 11, 2007

  [ 69 votes ]   [ Discuss This Article ]
By AK Smith, et al. • • December 15, 2007

Chronic Fatigue Syndrome (CFS) is a debilitating disorder of unknown etiology with no known lesions, diagnostic markers or therapeutic intervention. The pathophysiology of CFS remains elusive, although abnormalities in the central nervous system (CNS) have been implicated, particularly hyperactivity of the serotonergic (5-hydroxytryptamine; 5-HT) system and hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis.

Since alterations in 5-HT signaling can lead to physiologic and behavioral changes, a genetic evaluation of the 5-HT system was undertaken to identify serotonergic markers associated with CFS and potential mechanisms for CNS abnormality.

A total of 77 polymorphisms in genes related to serotonin synthesis (TPH2), signaling (HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, and HTR7), transport (SLC6A4), and catabolism (MAOA) were examined in 137 clinically evaluated subjects (40 CFS, 55 with insufficient fatigue, and 42 non-fatigued, NF, controls) derived from a population-based CFS surveillance study in Wichita, Kansas.

  • Of the polymorphisms examined, three markers (-1438G/A, C102T, and rs1923884), all located in the 5-HT receptor subtype HTR2A, were associated with CFS when compared to NF controls.
  • Additionally, consistent associations were observed between HTR2A variants and quantitative measures of disability and fatigue in all subjects.
  • The most compelling of these associations was with the A allele of -1438G/A (rs6311) which is suggested to have increased promoter activity in functional studies.
  • Further, in silico analysis revealed that the -1438 A allele creates a consensus binding site for Th1/E47, a transcription factor implicated in the development of the nervous system. Electrophoretic mobility shift assay supports allele-specific binding of E47 to the A allele but not the G allele at this locus.
  • These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS.

    Source: Psychoneuroendocrinology. Dec 11 2007 [E-pub ahead of print] PMID: 18079067, by Smith AK, Dimulescu I, Falkenberg VR, Narasimhan S, Heim C, Vernon SD, Rajeevan MS. Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

    Post a Comment

    Featured Products From the ProHealth Store
    FibroSleep™ Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products

    Article Comments

    Be the first to comment on this article!

    Post a Comment

    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Subscribe Now!
    Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
     Privacy Guaranteed  |  View Archives

    Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

    Featured Products

    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health

    Natural Remedies

    The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
    Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
    Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
    Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
    Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS

    What is Fibromyalgia?
    Fibromyalgia Diagnosis
    Fibromyalgia Symptoms
    Fibromyalgia Causes
    Fibromyalgia Treatments
    Fibromyalgia Diet
    Fibromyalgia Medications
    M.E. & CFS
    What is M.E./CFS?
    M.E./CFS Diagnosis
    M.E./CFS Symptoms
    M.E./CFS Causes
    M.E./CFS Treatments
    M.E./CFS Diet
    M.E./CFS Medications
    What is Lyme Disease?
    Lyme Disease Diagnosis
    Lyme Disease Symptoms
    Lyme Disease Causes
    Lyme Disease Treatments
    Lyme Disease Diet
    Lyme Disease Medications
    M.E. & CFS
    Lyme Disease
    General Health
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing