Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Cistus: A Natural Antibiotic, Antiviral, and Biofilm Buster

ACTION ALERT: Improve US Chronic Pain Care

Big step towards cure for HIV and other lifelong viral infections

SURVEY RESULTS: Attitudes About Fatigue

How Omega-3 Fights Depression

Superfood Trio: Ginger, Turmeric, and Carrots?

Rejuvenate Your Skin Naturally With Sea Buckthorn Oil

A Smile

Can Drinking More Water Help You Lose Weight?

Resveratrol’s Link to Slowing Alzheimer’s

 
Print Page
Email Article

Serotonergic agents and the irritable bowel syndrome: What goes wrong? - Source: Current Opinion in Pharmacology. Jul 28, 2008

  [ 28 votes ]   [ 1 Comment ]
By Robin Spiller • www.ProHealth.com • August 6, 2008


[Note: 5HT is serotonin. It is a neurotransmitter synthesized in the central nervous system and gastrointestinal tract and is found in many fruits and vegetables. A 5HT agonist would support increased serotonin level; a 5HT antagonist would support reduced serotonin level.] It is now nine years since the first large randomized controlled trials showed the benefit of a 5HT(3) antagonist in irritable bowel syndrome (IBS) with diarrhea (IBS-D) and a 5HT(4) partial agonist in IBS with constipation (IBS-C). Although both of these drugs have now been withdrawn because of rare complications (ischemic colitis and thrombotic episodes respectively), their clinical effectiveness has stimulated substantial advances in our understanding of the physiological role of serotonin and its disturbance in IBS. 5HT-containing enteroendocrine cells are most numerous in the duodenum and colon and are responsive to a range of stimuli including tastants, mechanic force and short chain fatty acids. Several studies have described an excess of 5HT in IBS-D and abnormally low 5HT availability in IBS-C. Serotonin transporter (SERT) is only weakly expressed in the colon, and whether this is further reduced in IBS is unclear with conflicting reports. SERT promoter polymorphisms are inconsistently related to IBS subtypes but appear to partly predict response to both 5HT(3) antagonists and 5HT(4) agonists. Stressors release serotonin, and 5HT(3) antagonists have been shown to inhibit the associated acceleration of colonic transit. Newer 5HT(3) antagonists and 5HT(4) agonists are under development. Their undoubted effectiveness in subgroups of IBS should stimulate further work to define biomarkers of both responsiveness and of risk of developing adverse events to improve the risk benefit balance for these potentially useful therapies. Source: Current Opinion in Pharmacology, Jul 28, 2008. [Epub ahead of print] PMID: 18672092, by Spiller R. Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK. [E-mail: Professor Robin Spiller robin.spiller@nottingham.ac.uk]




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Optimized Curcumin Longvida® FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

IBSD and IBSC
Posted by: sallynoname
Sep 5, 2008
The article assumes that these two categories are mutually exclusive and postulates that the same chemicals are high in one and low in the other. So what about people like myself who have both at different times?
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map