ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Single tick bite can pack double pathogen punch

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Higher vitamin D levels associated with better cancer prognosis

Genetic study suggests causal link between vitamin D deficiency and hypertension

Unsuspected aspect of immune regulation revealed: Role of B cells

Explaining 'Healthy' Obesity

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

 
Print Page
Email Article

Serotonergic agents and the irritable bowel syndrome: What goes wrong? - Source: Current Opinion in Pharmacology. Jul 28, 2008

  [ 28 votes ]   [ 1 Comment ]
By Robin Spiller • www.ProHealth.com • August 6, 2008


[Note: 5HT is serotonin. It is a neurotransmitter synthesized in the central nervous system and gastrointestinal tract and is found in many fruits and vegetables. A 5HT agonist would support increased serotonin level; a 5HT antagonist would support reduced serotonin level.] It is now nine years since the first large randomized controlled trials showed the benefit of a 5HT(3) antagonist in irritable bowel syndrome (IBS) with diarrhea (IBS-D) and a 5HT(4) partial agonist in IBS with constipation (IBS-C). Although both of these drugs have now been withdrawn because of rare complications (ischemic colitis and thrombotic episodes respectively), their clinical effectiveness has stimulated substantial advances in our understanding of the physiological role of serotonin and its disturbance in IBS. 5HT-containing enteroendocrine cells are most numerous in the duodenum and colon and are responsive to a range of stimuli including tastants, mechanic force and short chain fatty acids. Several studies have described an excess of 5HT in IBS-D and abnormally low 5HT availability in IBS-C. Serotonin transporter (SERT) is only weakly expressed in the colon, and whether this is further reduced in IBS is unclear with conflicting reports. SERT promoter polymorphisms are inconsistently related to IBS subtypes but appear to partly predict response to both 5HT(3) antagonists and 5HT(4) agonists. Stressors release serotonin, and 5HT(3) antagonists have been shown to inhibit the associated acceleration of colonic transit. Newer 5HT(3) antagonists and 5HT(4) agonists are under development. Their undoubted effectiveness in subgroups of IBS should stimulate further work to define biomarkers of both responsiveness and of risk of developing adverse events to improve the risk benefit balance for these potentially useful therapies. Source: Current Opinion in Pharmacology, Jul 28, 2008. [Epub ahead of print] PMID: 18672092, by Spiller R. Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK. [E-mail: Professor Robin Spiller robin.spiller@nottingham.ac.uk]




Join the Discussion Post a Comment 


IBSD and IBSC
Posted by: sallynoname
Sep 5, 2008
The article assumes that these two categories are mutually exclusive and postulates that the same chemicals are high in one and low in the other. So what about people like myself who have both at different times?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing