ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Single tick bite can pack double pathogen punch

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Higher vitamin D levels associated with better cancer prognosis

Genetic study suggests causal link between vitamin D deficiency and hypertension

Unsuspected aspect of immune regulation revealed: Role of B cells

Explaining 'Healthy' Obesity

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

 
Print Page
Email Article

New York Medical College Recruiting for Chronic Fatigue Syndrome (ME/CFS) Circulatory Function Testing Study – Ages 15-29

  [ 92 votes ]   [ Post a Comment ]
www.ProHealth.com • April 4, 2009


“We believe that this study will help to determine the specific cause of POTS in CFS and will point towards improved medical therapy for younger CFS patients.”

This study involving two days of testing at New York Medical College in Westchester County, New York, is focused on understanding circulatory factors that may explain and lead to effective therapies for the symptoms of 'chronic fatigue syndrome' (ME/CFS) in young people ages 15 - 29.

The study, led by pediatric physiologist Dr. Julian M Stewart, MD, PhD, Director of NYMC’s Center for Hypotension, offers the testing free (including testing of potentially helpful medications in relevant subjects) plus a small stipend.

To quote the study description:

What Comprises the Study Population? We are seeking patients aged 15-29 years old patients with chronic fatigue syndrome (CFS) with or without any overt form of cardiovascular or circulatory disease. While many young people with CFS have a form of overt chronic orthostatic intolerance (the inability to remain upright without symptoms) there are many others who do not.

“Yet the latter group may still have abnormalities of the small blood vessels, also called microvessels, that are most important in the regulation of blood volume and blood flow. Thus, some of the CFS patients have symptoms of chronic orthostatic intolerance such as dizziness, nausea, headache, pallor, and neurocognitive loss (difficulty thinking) which overlap with the case definition of CFS.

“Others may not have obvious symptoms while standing, but might still have blood vessel abnormalities (i.e., vascular dysfunction) that contribute to fatigue and might benefit from specific therapy.

"What is the hypothesis and importance? Blood flow abnormalities associated with the postural tachycardia syndrome (POTS) produce major disability in younger chronic fatigue syndrome (CFS) patients. These may be due to defects:

• In a fundamental signaling molecule called nitric oxide (NO)

• Or in its interaction with another molecule called angiotensin. In the current proposal we will determine how NO and angiotensin produce POTS in CFS patients and whether drugs that alter NO and angiotensin can improve patient health.

“We will subset CFS patients by POTS using upright tilt, and subgroup POTS based on noninvasive measurements of peripheral blood flow. Some patients who we denote low flow CFS/POTS have reduced peripheral blood flow, while others have normal flow.

“We will determine whether low flow CFS/POTS is due to decreased NO produced by nNOS and related to increased angiotensin-II (A-II) and oxidative stress. We will measure skin blood flow with lasers, and NO and angiotensin by intradermal microdialysis tiny tubes in the skin), and use local heating and chemical responses in the skin to a commonly used blocker of angiotensin called losartan. If losartan works in the skin we will try to treat low blood flow with oral losartan and measure the extent of improvement in blood flow throughout your body.

“Data suggest that NO is increased in normal flow CFS/POTS at least in the gut circulation causing pooling of blood during upright posture. We will determine whether this is true in the skin. If this is true in the skin, we will test whether a systemic medication called octreotide reduces orthostatic gut blood pooling and cutaneous microvascular NO dependent responses."

FOR MORE INFORMATION AND A SCREENING APPLICATION
To learn much more about the study and eligibility criteria, for contact information, and to access a Screening Application, go to the study listing on the NYMC site (http://www.nymc.edu/fhp/centers/syncope/Vascular%20Dysfunction%20in%20CFS.htm)





Join the Discussion Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing