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Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV Infection - Source: Journal of General Virology, Sep 30, 2009

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By Seiko Iwata, Hiroshi Kimura, et al. • www.ProHealth.com • October 6, 2009

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Chronic active Epstein-Barr virus (EBV) infection is a systemic EBV-positive lymphoproliferative disorder characterized by persistent or recurrent infectious mononucleosis-like symptoms in patients with no known immunodeficiency. The detailed pathogenesis of the disease is unknown, and no standard treatment regimen has been developed.

EBV gene expression was analyzed in peripheral blood samples collected from 24 patients with chronic active EBV infection. The expression levels of six latent and two lytic EBV genes were quantified by real-time reverse transcription (RT)-PCR.

• EBV-encoded small RNA (EBER) 1 and BamHI-A rightward transcripts (BARTs) were abundantly detected in all patients,

• And latent membrane protein (LMP) 2 was observed in most patients.

• EBV nuclear antigen (EBNA) 1 and LMP1 were detected less frequently and were expressed at lower levels.

• EBNA2 and the two lytic genes were not detected in any of the patients.

• The pattern of latent gene expression was determined to be latency type II.

• EBNA1 was detected more frequently and at higher levels in the in clinically active patients.

Quantifying EBV gene expression is useful in clarifying the pathogenesis of chronic active EBV infection and may provide information regarding a patient's disease prognosis, as well as possible therapeutic interventions.

Source: Journal of General Virology, Sep 30, 2009. PMID: 19793909, by Iwata S, Wada K, Tobita S, Gotoh K, Ito Y, Demachi-Okamura A, Shimizu N, Nishiyama Y, Kimura H. Department of Virology, Nagoya University Graduate School of Medicine. [E-mail: hkimura@med.nagoya-u.ac.jp]


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