ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Proteins in brain employ resveratrol to exert antidiabetic effect, researchers establish

  [ 28 votes ]   [ Post a Comment ]
www.ProHealth.com • October 16, 2009

previous article next article

“Our study shows that the brain plays an important role in mediating resveratrol’s anti-diabetic actions, and it does so independent of changes in food intake and body weight.” - Roberto Coppari, PhD

A naturally produced molecule called resveratrol, a compound found for example in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet. The findings from a new University of Texas Southwestern Medical Center study suggest that when acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes.

Prior research has shown that the compound exerts anti-diabetic actions when fed to animals with type 2 diabetes (non-insulin dependent diabetes mellitus). But it has been unclear which tissues in the body mediated these effects.

“Our study shows that the brain plays an important role in mediating resveratrol’s anti-diabetic actions, and it does so independent of changes in food intake and body weight,” said Dr. Roberto Coppari, PhD, assistant professor of internal medicine at UT Southwestern and senior author of the study ("Central Administration of Resveratrol Improves Diet-Induced Diabetes" ), published online Oct 9 in the journal Endocrinology.

“These animals were overrun with fat and many of their organs were inflamed. But when we delivered resveratrol in the brain, it alleviated inflammation in the brain,” added Dr. Coppari.

Dr. Coppari emphasized that his study does not support the conclusion that consuming products made from red grapes, such as red wine, could alleviate diabetes. “The main reason is that resveratrol does not cross the blood brain barrier efficiently,” he said. “In order for the brain to accumulate the same dose of resveratrol delivered in our study, the amounts of red wine needed daily would surely cause deleterious effects, especially in the liver. Rather, our study suggests that resveratrol’s analogs that selectively target the brain may help in the fight against diet-induced diabetes.”

For the study, the researchers investigated what happens when resveratrol acts only in the brain. Specifically, they wanted to know whether resveratrol injected in the brain activated a group of proteins called sirtuins, which are found throughout the body and thought to underlie many of the beneficial effects of calorie restriction.

• Previous animal research has shown that when these proteins are activated by resveratrol, diabetes is improved.

• In addition, drugs activating sirtuins currently are being tested as anti-diabetic medications in human trials, Dr. Coppari said.

In one group of animals, researchers injected resveratrol directly into the brain; another group received a saline-based placebo. All the surgically treated animals consumed a high-fat diet before and after the surgery.

• Dr. Coppari said the insulin levels of the animals treated with the placebo solution rose increasingly higher post-surgery. “That’s a normal outcome because insulin sensitivity decreases the longer you keep an animal on a high-fat diet.”

• Insulin levels in the mice given resveratrol, however, actually started to drop and were halfway to normal by the end of the five-week study period, even though the animals remained on a high-fat diet.

• In addition, the researchers found that resveratrol did indeed activate sirtuin proteins in the brain.

Dr. Coppari said the findings support his team’s theory that the brain plays a vital role in mediating the beneficial effects of resveratrol and that manipulation of brain sirtuins also may have other beneficial outcomes. “By knowing that the central nervous system is involved, pharmaceutical companies can begin to focus on developing drugs that selectively target sirtuins in the brain,” he said.

The next step, Dr. Coppari said, is to determine precisely which neurons in the brain are mediating the effects of the resveratrol…

The study was supported by the American Heart Association, National Institutes of Health and the American Diabetes Association.

Source: University of Texas Southwestern Medical Center news release, Oct 15, 2009, with modifications.


previous article
  Rating 3.4 (28 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing