Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

7 Natural Ways to Prevent Diabetes

8 Hacks to Slash Medication Costs

New Study Shows Optimized Curcumin Stops Inflammation

Relief from Common Digestive Distress

What Foods Can Help Fight the Risk of Chronic Inflammation?

SURVEY: Should Opioids Be Restricted for Chronic Illness?

Block The Vascular Origins Of Cognitive Decline

Curcumin: Your Secret Weapon to Speed Muscle Recovery After Intense Exercise

 
Print Page
Email Article

Proteins in brain employ resveratrol to exert antidiabetic effect, researchers establish

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 16, 2009


“Our study shows that the brain plays an important role in mediating resveratrol’s anti-diabetic actions, and it does so independent of changes in food intake and body weight.” - Roberto Coppari, PhD

A naturally produced molecule called resveratrol, a compound found for example in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet. The findings from a new University of Texas Southwestern Medical Center study suggest that when acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes.

Prior research has shown that the compound exerts anti-diabetic actions when fed to animals with type 2 diabetes (non-insulin dependent diabetes mellitus). But it has been unclear which tissues in the body mediated these effects.

“Our study shows that the brain plays an important role in mediating resveratrol’s anti-diabetic actions, and it does so independent of changes in food intake and body weight,” said Dr. Roberto Coppari, PhD, assistant professor of internal medicine at UT Southwestern and senior author of the study ("Central Administration of Resveratrol Improves Diet-Induced Diabetes" ), published online Oct 9 in the journal Endocrinology.

“These animals were overrun with fat and many of their organs were inflamed. But when we delivered resveratrol in the brain, it alleviated inflammation in the brain,” added Dr. Coppari.

Dr. Coppari emphasized that his study does not support the conclusion that consuming products made from red grapes, such as red wine, could alleviate diabetes. “The main reason is that resveratrol does not cross the blood brain barrier efficiently,” he said. “In order for the brain to accumulate the same dose of resveratrol delivered in our study, the amounts of red wine needed daily would surely cause deleterious effects, especially in the liver. Rather, our study suggests that resveratrol’s analogs that selectively target the brain may help in the fight against diet-induced diabetes.”

For the study, the researchers investigated what happens when resveratrol acts only in the brain. Specifically, they wanted to know whether resveratrol injected in the brain activated a group of proteins called sirtuins, which are found throughout the body and thought to underlie many of the beneficial effects of calorie restriction.

• Previous animal research has shown that when these proteins are activated by resveratrol, diabetes is improved.

• In addition, drugs activating sirtuins currently are being tested as anti-diabetic medications in human trials, Dr. Coppari said.

In one group of animals, researchers injected resveratrol directly into the brain; another group received a saline-based placebo. All the surgically treated animals consumed a high-fat diet before and after the surgery.

• Dr. Coppari said the insulin levels of the animals treated with the placebo solution rose increasingly higher post-surgery. “That’s a normal outcome because insulin sensitivity decreases the longer you keep an animal on a high-fat diet.”

• Insulin levels in the mice given resveratrol, however, actually started to drop and were halfway to normal by the end of the five-week study period, even though the animals remained on a high-fat diet.

• In addition, the researchers found that resveratrol did indeed activate sirtuin proteins in the brain.

Dr. Coppari said the findings support his team’s theory that the brain plays a vital role in mediating the beneficial effects of resveratrol and that manipulation of brain sirtuins also may have other beneficial outcomes. “By knowing that the central nervous system is involved, pharmaceutical companies can begin to focus on developing drugs that selectively target sirtuins in the brain,” he said.

The next step, Dr. Coppari said, is to determine precisely which neurons in the brain are mediating the effects of the resveratrol…

The study was supported by the American Heart Association, National Institutes of Health and the American Diabetes Association.

Source: University of Texas Southwestern Medical Center news release, Oct 15, 2009, with modifications.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map