Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Essential Oils - How and Where to Use Them

The Link Between Vitamin C And Optimal Immunity

SURVEY: What Is Your Diagnosis?

Liposomes Deliver Optimal Nutrient Absorption

Why Does Your Nose Run When It's Cold Outside?

What's So Great About Grape Seed?

How Your Mitochondria Influence Your Health

 
Print Page
Email Article

Pain Drug Can Cancel Out Low-Dose Aspirin’s Anti-Clotting Action

  [ 43 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 15, 2009


Aspirin’s blood thinning effect was thought to counteract Celebrex’s clot-promoting potential - but the reverse may occur with low doses.

Millions of Americans take Celebrex (generic name celecoxib) for arthritis or other pain. Many, if they are middle-aged or older, also take a low-dose aspirin tablet daily to reduce the risk of heart attack and stroke. Yet they may be getting little protection, because Celebrex keeps the aspirin from doing its job effectively, a new study suggests.

In laboratory studies, University of Michigan researchers found that several coxibs, the drug class to which Celebrex belongs,(1) interfere with aspirin’s ability to discourage blood clots, if the aspirin is taken in low doses. In animal studies, the researchers found more clumping of platelets – the initial stage of clotting – in blood from animals given Celebrex and low-dose aspirin than in animals given only low-dose aspirin.

The report appears in the Dec 1 issue of the Proceedings of the National Academy of Sciences.(2)

Low-dose aspirin may be recommended for several reasons:

• Doctors frequently advise daily low-dose aspirin (81 mg) for patients who have heart conditions, notably a serious form of angina known as unstable angina, or for patients who are at risk of second heart attacks. Aspirin is well-known for its ability to discourage formation of blood clots that can lead to heart attack and stroke.

• In addition, arthritis patients who take Celebrex regularly are often put on low-dose aspirin because this is thought to counteract Celebrex’s own potential clot-promoting effect.

“There are many people who take low-dose aspirin, perhaps as many as half of men over 50. If they are also prescribed Celebrex for arthritis or other pain, our results suggest that the Celebrex will probably interfere with the aspirin’s action,” says William L. Smith, PhD,  the study’s senior author and chair of the biochemistry department at University of Michigan Medical School.

“The greatest risk is having people take Celebrex who are taking aspirin for cardiovascular problems that are known to be mitigated by aspirin, including patients with unstable angina or those at risk for a second heart attack,” he says. In unstable angina, small clots form in arteries and interfere with blood flow.

Previous studies of healthy subjects found no ill effect on blood clotting when Celebrex was combined with aspirin at higher doses, specifically a daily “regular” aspirin tablet (324 mg), Smith notes.

• So it may be that a higher aspirin dose, or spreading out the time between taking low-dose aspirin and Celebrex, will allow aspirin to be effective.

• However, aspirin’s undesirable effects on the gastrointestinal tract at higher doses when taken long-term would have to be taken into account.

First, though, the effect seen in the U-M study needs to be replicated in human studies, perhaps in older patients who have conditions such as rheumatoid arthritis, says Smith. If the effect holds true in people, it will be important to determine if a balance in dose and/or dose regimens can be found so that aspirin and Celebrex can both be effective.

Funding: National Institutes of Health, Heart and Stroke Foundation of Canada

References
1. Celebrex is one member of a class of drugs known as coxibs or COX-2 inhibitors, developed to selectively block the action of pain-causing enzymes while minimizing side effects such as gastrointestinal problems. Celebrex, a non-steroidal anti-inflammatory drug (NSAID) is the only coxib currently on the market in the US.

2. Article citation: “Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1” PNAS, Dec 1, 2009
___
Source: University of Michigan Health System press release, Dec 15, 2009




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra ATP+, Double Strength Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing