Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Decreased levels of vitamin D associated with reduced methylation in African American teens

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

8 Hacks to Slash Medication Costs

Relief from Common Digestive Distress

New Study Shows Optimized Curcumin Stops Inflammation

7 Natural Ways to Prevent Diabetes

Block The Vascular Origins Of Cognitive Decline

What Foods Can Help Fight the Risk of Chronic Inflammation?

Curcumin: Your Secret Weapon to Speed Muscle Recovery After Intense Exercise

 
Print Page
Email Article

Breakthrough made in diagnosing chronic fatigue syndrome, Japanese researchers report

  [ 77 votes ]   [ 9 Comments ]
www.ProHealth.com • January 10, 2010


[Note: The following press release was distributed Jan 11 via from the Japanese news site Daily Yomiuri Shimbun. We have not yet identified a journal article or other publication further detailing the study.* Meanwhile, others argue that ME/CFS patients often test low in alpha-MSH, not high, so details will be welcome.]

Researchers have discovered a protein in blood that can be used to diagnose chronic fatigue syndrome, a breakthrough that could help detect the ailment during physical checkups.

There are diagnostic criteria for chronic fatigue syndrome - a disorder involving extreme fatigue of unknown cause that continues for at least six months - that rely primarily on subjective symptoms, but there have been no objective markers such as blood tests.

The research team led by Hiroshi Kiyama, a professor of anatomy [in the Graduate School of Medicine] at Osaka City University, examined the intermediate lobes of the pituitary glands of rats in which they induced extreme fatigue by making them exercise for five consecutive days. They found that the lobes excreted extraordinarily high amounts of a protein called alpha-MSH and that alpha-MSH levels in the animals' blood also increased.

The neurotransmitter dopamine inhibits the secretion of alpha-MSH, but the rats' ability to produce dopamine declined as their fatigue grew.

The group also tested the levels of alpha-MSH in the blood of 57 people diagnosed with chronic fatigue syndrome and the blood of 30 healthy people.

The average level among the 37 people who had been diagnosed with chronic fatigue syndrome less than five years before was about 50 percent higher than in the healthy people.

Source: Daily Yomiuri Shimbun (Japan) press release Jan 11, 2009

* For abstracts of past reports by Hirosi Kiyama and colleagues involving alpha-MSH, see http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kiyama%20H%22%5BAuthor%5D%20alpha-MSH




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

apparently this is not very new discovery...
Posted by: carlosams
Jan 11, 2010
Have a look on this article, they also mention that there is a deficiency of this hormone in 100% of CFS patients. So instead of 50% higher levels, they point a deficiency.
Reply Reply

 
I forgot to attach the article...
Posted by: carlosams
Jan 11, 2010
http://www.moldwarriors.com/msh-info.htm

 


Apparently this is not very new discovery...
Posted by: carlosams
Jan 11, 2010
Have a look on this article, they also mention that there is a deficiency of this hormone in 100% of CFS patients. So instead of 50% higher levels, they point a deficiency. http://www.moldwarriors.com/msh-info.htm Now with the link.
Reply Reply

 
alpha-MSH
Posted by: Lono83
Jan 13, 2010
This test is very easy to get in the US and should be covered by insurance. The test is MSH from LabCorp (test # 010421).

A couple of additional things to note about alpha-MSH, it's incredibly important-- it assists with sleep regulation, inflammation, digestion, pain perception and a host of other things that affect/debilitate people with CFS/ME & Fibro.

And many, many folks with CFS/ME who have had this test done are deficient!

Also, note that normal values for MSH are 35-81.

And if you have low MSH, you should also get your VIP (vasoactive intestinal peptide) tested. Also, from LabCorp (test #10397). Many CFS/ME folks have abnormally low levels of both.

 


alpha-MSH
Posted by: Lono83
Jan 13, 2010
This test is very easy to get in the US and should be covered by insurance. The test is MSH from LabCorp (test # 010421). A couple of additional things to note about alpha-MSH, it's incredibly important-- it assists with sleep regulation, inflammation, digestion, pain perception and a host of other things that affect/debilitate people with CFS/ME & Fibro. And many, many folks with CFS/ME who have had this test done are deficient! Also, note that normal values for MSH are 35-81. And if you have low MSH, you should also get your VIP (vasoactive intestinal peptide) tested. Also, from LabCorp (test #10397). Many CFS/ME folks have abnormally low levels of both.
Reply Reply

Supplementing?
Posted by: bobdstrategy
Jan 13, 2010
Carlosams & Lono83, thanks for your informative comments and info. I wanted to ask if you (or anyone)have any thoughts on specific supplements or ways to help with this deficiency?
Reply Reply

MSH supplements
Posted by: Lono83
Jan 13, 2010
I'm not aware of any supplements for MSH (and MSH can't be prescribed in the US). I've heard of some people trying to use Melanotan to raise their MSH, but I don't have any info on whether it was successful (Melanotan is an MSH analogue).
Reply Reply

my take on this
Posted by: Sandy10m
Jan 21, 2010
My take on this is that CFS evolves in every person differently. Hypothetically, if you knew the actual cause of CFS (assuming there is only one cause), and intentionally infected 100 people for a study, each person will show different levels of MSH at different times, and each will show different levels of adrenal hormone at different times, and each will show different levels of mitochondrial damage at different times, etc etc. And this is assuming there is only ONE cause. However, I believe that we have multiple causes, that mast of us are lumped into CFS because the category is there. We will probably have clinically confirmed variations, such as Viral CFS, or Toxin CFS, or Psychological CFS. And then we will probably have sub-groups inside that, such as Viral CFS (XMRV) and Viral CFS (HPV) and Viral CFS (EBV), etc. Unfortunately, our condition is NOT simple, otherwise the researchers would have found something by now. The main problem is that people representing ALL the CFS conditions listed above are taking part in clinical trials and testing. We need to start figuring out which type(s) of CFS we all have, based upon this testing. We need to be tested for viruses (like XMRV), toxins (like DDT), mitochondrial function (including MSH), and then report on which subgroup we represent when we are included in future clinical trials. I, for one, would LOVE to see a clinical trial which first screens the CFS patients for one particular problem (such as XMRV) and then does a new screening for some other problem (such as MSH). I think we would see many more correlations than what we see now.
Reply Reply

This is refreshing
Posted by: richard m
Jan 22, 2010
Research into the underlying biochemical causes of fatigue, sleep, and stress is the only way forward for CFS. After 20 years of looking for a serious viral/immune cause for the disease there is a spectacular lack of concrete data. People with the disease test negative for nearly every immunological test under the sun. It is patently obvious to all those in my ME/CFS support group in New Zealand that the disorder in neurological: the three main symptoms beside fatige being brain fog, sleep deprivation, and emotional sensitivity to stress. It's time to look at abnormalities in the nervous system and the brain. Hope you all get well soon. Richard M.
Reply Reply


Post a Comment

 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
SAD? Coping with Seasonal Affective Disorder
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map