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Omega-3 fatty acids [fish oil] for neuropathic pain: Case series – Source: Clinical Journal of Pain, Feb 2010

  [ 89 votes ]   [ 2 Comments ]
By Gordon D Ko, et al. • • January 24, 2010

[Note: neuropathic pain is pain and tenderness without detectable tissue injury, or pain persisting long after tissue damage is resolved. Malfunctioning nervous system signaling is the cause of pain.]

Objective: The aim of this case series study was to investigate and report on patients with neuropathic pain who responded to treatment with omega-3 fatty acids.

Methods: Five patients with different underlying diagnoses including:

• Cervical radiculopathy,

• Thoracic outlet syndrome,

• Fibromyalgia,

• Carpal tunnel syndrome,

• Burn injury…

…were treated with high oral doses of omega-3 fish oil (varying from 2400 to 7200 mg/day of EPA-DHA).

Outcome measures were obtained pretreatment and posttreatment. These included validated surveys (short-form McGill Pain questionnaire, DN4 neuropathic pain scale, Pain Detect Questionnaire), objective clinical tools (Jamar grip strength, Lafayette dynamometry, tender point algometry) and EMG Nerve Conduction studies.

Results: These patients had:

• Clinically significant pain reduction, [and]

• Improved function…

…as documented with both subjective and objective outcome measures up to as much as 19 months after treatment initiation.

No serious adverse effects were reported.

Conclusions: This first-ever reported case series suggests that omega-3 fatty acids may be of benefit in the management of patients with neuropathic pain.

Further investigations with randomized controlled trials in a more specific neuropathic pain population would be warranted.

Source: Clinical Journal of Pain, Feb 2010;26(2):168-72. PMID: 20090445, by Ko GD, Nowacki NB, Arseneau L, Eitel M, Hum A. Canadian Centre for Integrative Medicine and the Physiatry Interventional Pain Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. [E-mail:]

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Article Comments Post a Comment

Dose for Omega-3
Posted by: MandMs
Jan 27, 2010
The author mentioned a large range for the size of the dose of Omega-3 fatty acids, with the implication that the lower dose would be expected to yield the same results. Anyone else read it that way? Is anyone currently taking Omega-3 fatty acids and how's it working?
Reply Reply

Fish oil dosage and effect
Posted by: sulis
Jan 27, 2010
I started taking Lovaza (a prescription fish oil supplement) 1000 mg capsule per day over a month ago because of problems with inflammation. My overall pain level has decreased about 1-2 points on a 10 scale most days, some days more. I can't take more because of bleeding problems, but the results of this study make sense to me.
Reply Reply
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