ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

How Glutathione Can Save Your Life

Reversing Neurodegeneration with a New Magnesium Compound

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

Scientists discover how to 'switch off' autoimmune diseases

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

Surprising discovery: HIV hides in gut, evading eradication

New estrogen-based compound suppresses binge-like eating behavior in female mice

 
Print Page
Email Article

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV – Source: Virology, Jan 26, 2010

  [ 6 votes ]   [ Discuss This Article ]
By Kristin Stieler, Nicole Fischer, et al. • www.ProHealth.com • February 1, 2010


Recently, the first human infection with an exogenous gammaretrovirus (XMRV) was reported.

In its initial description, XMRV was confined to prostate stromal fibroblasts [cells in connective tissue], although subsequent reports demonstrated XMRV protein expression in prostate epithelial cells [in the organ’s lining].

Most recently, XMRV has been detected in blood cells of patients with chronic fatigue syndrome.

The aim of this study was to elucidate the transmission routes and tissue tropism [tissue that supports the growth] of XMRV by comparing its host range, receptor usage and LTR functionality with other MLV isolates. [the LTR or “long terminal repeat” of a retrovirus “is the control center for gene expression.” MLV is amphotropic murine leukemia virus.]

• We demonstrate using pseudotype experiments that XMRV Env mediates efficient infection of cells from different species.

• We show that replication competent XMRV infects various human cell types, including hematopoietic cell lines and prostate stromal fibroblasts. [Hematopoietic stem calls, found in the bone marrow, give rise to all the blood cell types.]

• XMRV-LTR activity is significantly higher in the prostate cancer cell line LNCaP and in prostate stromal fibroblasts, compared to other cell types tested and could be one factor contributing to efficient viral spread in prostate tissue.

Source: Virology, Jan 26, 2010. PMID: 20110097, by Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N. Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Hamburg, Germany; Heinrich-Pette-Institute, Hamburg, Germany; Institut de Genetique Moleculaire de Montpellier, Montpellier, France. [E-mail: nfischer@uke.de]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing