Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Essential Oils - How and Where to Use Them

The Link Between Vitamin C And Optimal Immunity

SURVEY: What Is Your Diagnosis?

What's So Great About Grape Seed?

Liposomes Deliver Optimal Nutrient Absorption

Why Does Your Nose Run When It's Cold Outside?

How Your Mitochondria Influence Your Health

 
Print Page
Email Article

A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss - Source: Archives of Internal Medicine, Jan 25, 2010

  [ 19 votes ]   [ Discuss This Article ]
By William S. Yancy Jr, MD, MHS, et al. • www.ProHealth.com • February 5, 2010


[Note: The ketogenic “Atkins-type” diet used in this trial is high-fat, adequate-protein, low-carb. It is called ketogenic because it forces the body to burn fats rather than carbs for energy. While carbs are converted into glucose for energy, fats are converted by the liver into fatty acids and “ketone bodies,” which replace glucose as an energy source. Orlistat is a prescription drug that acts to limit the digestive tract’s ability to digest and absorb fats consumed in the diet.]

Background:  Two potent weight loss therapies...

• A low-carbohydrate, ketogenic diet (LCKD),

• And orlistat therapy combined with a low-fat diet (O + LFD),

…are available to the public but, to our knowledge, have never been compared.

Methods: Overweight or obese outpatients (n = 146) from the Department of Veterans Affairs primary care clinics in Durham, North Carolina, were randomized to either LCKD instruction (initially, less than 20 grams of carbohydrate daily) or orlistat therapy, 120 mg orally 3 times daily, plus low-fat diet instruction (less than 30% energy from fat, 500 to 1000 kcal/d deficit) delivered at group meetings over 48 weeks.

Main outcome measures were body weight, blood pressure, fasting serum lipid, and glycemic parameters.

Results: The mean age was 52 years and mean body mass index was 39.3 (calculated as weight in kilograms divided by height in meters squared); 72% were men, 55% were black, and 32% had type 2 diabetes mellitus. Of the study participants, 57 of the LCKD group (79%) and 65 of the O + LFD group (88%) completed measurements at 48 weeks.

• Weight loss was similar for the low-carbohydrate, ketogenic diet (expected mean change, –9.5%) and the orlistat plus low-fat diet (–8.5%) (P = .60 for comparison) groups.

• The low-carbohydrate, ketogenic diet had a more beneficial impact than orlistat plus low-fat diet on systolic (–5.9 vs 1.5 mm Hg) and diastolic (–4.5 vs 0.4 mm Hg) blood pressures (P < .001 for both comparisons).

• High-density lipoprotein [so-called ‘good’] cholesterol and triglyceride levels improved similarly within both groups.

• Low-density lipoprotein [so-called ‘bad’] cholesterol levels improved within the orlistat plus low-fat diet group only,

• Whereas glucose, insulin, and hemoglobin A1c levels improved within the low-carbohydrate, ketogenic diet group only; comparisons between groups, however, were not statistically significant.

Conclusion: In a sample of medical outpatients, a low-carbohydrate, ketogenic diet led to similar improvements as orlistat plus low-fat diet for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.

Trial Registration: clinicaltrials.gov Identifier: NCT00108524

Source: Archives of Internal Medicine, Jan 25, 2010;170(2):136-145. PMID: 20101008, by Yancy WS, Westman EC, McDuffie JR, Grambow SC, Jeffreys AS, Bolton J, Chalecki A, Oddone EZ. Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center; Departments of Medicine and Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA. [E-mail: yancy006@mc.duke.edu]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Breaking Through the Mental Fog Breaking Through the Mental Fog
Safely Burn Away Body Fat Safely Burn Away Body Fat
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing