Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

 
Print Page
Email Article

A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss - Source: Archives of Internal Medicine, Jan 25, 2010

  [ 19 votes ]   [ Discuss This Article ]
By William S. Yancy Jr, MD, MHS, et al. • www.ProHealth.com • February 5, 2010


[Note: The ketogenic “Atkins-type” diet used in this trial is high-fat, adequate-protein, low-carb. It is called ketogenic because it forces the body to burn fats rather than carbs for energy. While carbs are converted into glucose for energy, fats are converted by the liver into fatty acids and “ketone bodies,” which replace glucose as an energy source. Orlistat is a prescription drug that acts to limit the digestive tract’s ability to digest and absorb fats consumed in the diet.]

Background:  Two potent weight loss therapies...

• A low-carbohydrate, ketogenic diet (LCKD),

• And orlistat therapy combined with a low-fat diet (O + LFD),

…are available to the public but, to our knowledge, have never been compared.

Methods: Overweight or obese outpatients (n = 146) from the Department of Veterans Affairs primary care clinics in Durham, North Carolina, were randomized to either LCKD instruction (initially, less than 20 grams of carbohydrate daily) or orlistat therapy, 120 mg orally 3 times daily, plus low-fat diet instruction (less than 30% energy from fat, 500 to 1000 kcal/d deficit) delivered at group meetings over 48 weeks.

Main outcome measures were body weight, blood pressure, fasting serum lipid, and glycemic parameters.

Results: The mean age was 52 years and mean body mass index was 39.3 (calculated as weight in kilograms divided by height in meters squared); 72% were men, 55% were black, and 32% had type 2 diabetes mellitus. Of the study participants, 57 of the LCKD group (79%) and 65 of the O + LFD group (88%) completed measurements at 48 weeks.

• Weight loss was similar for the low-carbohydrate, ketogenic diet (expected mean change, –9.5%) and the orlistat plus low-fat diet (–8.5%) (P = .60 for comparison) groups.

• The low-carbohydrate, ketogenic diet had a more beneficial impact than orlistat plus low-fat diet on systolic (–5.9 vs 1.5 mm Hg) and diastolic (–4.5 vs 0.4 mm Hg) blood pressures (P < .001 for both comparisons).

• High-density lipoprotein [so-called ‘good’] cholesterol and triglyceride levels improved similarly within both groups.

• Low-density lipoprotein [so-called ‘bad’] cholesterol levels improved within the orlistat plus low-fat diet group only,

• Whereas glucose, insulin, and hemoglobin A1c levels improved within the low-carbohydrate, ketogenic diet group only; comparisons between groups, however, were not statistically significant.

Conclusion: In a sample of medical outpatients, a low-carbohydrate, ketogenic diet led to similar improvements as orlistat plus low-fat diet for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.

Trial Registration: clinicaltrials.gov Identifier: NCT00108524

Source: Archives of Internal Medicine, Jan 25, 2010;170(2):136-145. PMID: 20101008, by Yancy WS, Westman EC, McDuffie JR, Grambow SC, Jeffreys AS, Bolton J, Chalecki A, Oddone EZ. Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center; Departments of Medicine and Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA. [E-mail: yancy006@mc.duke.edu]





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map