ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Vitamin D controls T cell antigen receptor signaling and activation of human T cells – Source: Nature Immunology, Mar 7, 2010

  [ 142 votes ]   [ Discuss This Article ]
By Marina Rode von Essen, Carsten Geisler, et al. • www.ProHealth.com • March 12, 2010


[Note: The main job of the body’s T cells is to fight infection. These Danish researchers found that when T cells encounter a pathogen, they expose a vitamin D receptor that searches for vitamin D, and they will not activate without it.]

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-?1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells.

However, TCR triggering led to an upregulation of ~75-fold in PLC-?1 expression, which correlated with greater TCR responsiveness.

Induction of PLC-?1 was dependent on vitamin D and expression of the vitamin D receptor (VDR).

Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway.

Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-?1, which are required for subsequent classical TCR signaling and T cell activation.

Source: Nature Immunology, Mar 7, 2010. doi:10.1038/ni.1851 by von Essen MR, Kongsbak M, Schjerling P,  Olgaard K, Odum N, Geisle C. Department of International Health, Immunology and Microbiology; Center for Healthy Aging, Faculty of Health Sciences; Department of Biology, Faculty of Science; Institute of Sports Medicine and Department of Nephrology, Bispebjerg Hospital, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark. [E-mail: cge@sund.ku.dk]





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 5000 IU Mitochondria Ignite™ with NT Factor® Vitamin D3 1000 IU

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 5000 IU Vitamin D3 5000 IU
Give Your Body a Boost With the Sunshine Vitamin
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Vitamin D3 1000 IU Vitamin D3 1000 IU
Crucial nutrient for strong bones, heart and immune health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map