ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

7 Best Foods You Can Eat

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

The Gut Microbiome and the Brain

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CoQ10 supplementation reduces statin-related muscle pain in randomized trial

Plant used in traditional Chinese medicine may treat metabolic diseases and obesity

Controlling obesity with potato extract

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections

Proton pump inhibitors decrease diversity in gut microbiome, increase risk for complications

 
Print Page
Email Article

Vitamin D controls T cell antigen receptor signaling and activation of human T cells – Source: Nature Immunology, Mar 7, 2010

  [ 142 votes ]   [ Discuss This Article ]
By Marina Rode von Essen, Carsten Geisler, et al. • www.ProHealth.com • March 12, 2010


[Note: The main job of the body’s T cells is to fight infection. These Danish researchers found that when T cells encounter a pathogen, they expose a vitamin D receptor that searches for vitamin D, and they will not activate without it.]

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-?1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells.

However, TCR triggering led to an upregulation of ~75-fold in PLC-?1 expression, which correlated with greater TCR responsiveness.

Induction of PLC-?1 was dependent on vitamin D and expression of the vitamin D receptor (VDR).

Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway.

Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-?1, which are required for subsequent classical TCR signaling and T cell activation.

Source: Nature Immunology, Mar 7, 2010. doi:10.1038/ni.1851 by von Essen MR, Kongsbak M, Schjerling P,  Olgaard K, Odum N, Geisle C. Department of International Health, Immunology and Microbiology; Center for Healthy Aging, Faculty of Health Sciences; Department of Biology, Faculty of Science; Institute of Sports Medicine and Department of Nephrology, Bispebjerg Hospital, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark. [E-mail: cge@sund.ku.dk]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Vitamin D3 1000 IU Vitamin D3 1000 IU
Crucial nutrient for strong bones, heart and immune health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing