ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Risk factors in familial forms of celiac disease – Source: World Journal of Gastroenterology, Apr 21, 2010

  [ 36 votes ]   [ Post a Comment ]
By Hugh James Freeman, MD, CM, FRCPC, FACP • www.ProHealth.com • April 22, 2010

previous article next article

[Note: To read the full text of this article free, click here. It has important implications for at-risk families.]

Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in America and Australia where immigration of Europeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada.

Within these so-called "general" celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease.

• Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted.

• Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2 [associated with celiac disease and a constellation of other immune disorders such as type 1 diabetes, RA, MS, psoriasis].

• Both structural changes in the small bowel architecture occur along with functional changes in permeability, even in asymptomatic first-degree relatives.

• Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives - as well as intestinal lymphoma.

• Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.

Source: World Journal of Gastroenterology, Apr 21, 2010;16(15):1828-31. PMID: 20397258, by Freeman HJ. Department of Medicine, University of British Columbia Hospital, Vancouver, BC, Canada. [Email: hugfree@shaw.ca]



previous article
  Rating 3.1 (36 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

FDA Says Sponsors of Chronic Fatigue Syndrome Drugs can Rely on Patient-Reported Outcomes [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing