ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

National Institutes Of Health Discovers Protective Effects Of Coffee

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Researchers’ discovery may explain difficulty in treating Lyme disease

Discovering Coffee's Unique Health Benefits

Why So Many Arthritis Sufferers Fail to Find Relief

 
Print Page
Email Article

Vascular oxidative stress and inflammation increase with age: Ameliorating effects of alpha-lipoic acid supplementation – Source: Annals of the New York Academy of Sciences, Aug 2010

  [ 11 votes ]   [ Discuss This Article ]
By L Li, et al. • www.ProHealth.com • September 16, 2010


Increased oxidative stress and inflammation causally contribute to cardiovascular diseases, for which advanced age is a major risk factor.

We found that:

• Indicators of oxidative stress, including NADPH oxidase activity and superoxide levels, were significantly increased in aortas of old (22-24 months) versus young (3-4 months) male F344 rats, whereas superoxide dismutase (SOD) activity was decreased. Aortic mRNA and protein levels of NOX4, the principal catalytic subunit of NADPH oxidase in vascular cells, also were increased with age, but not NOX2 and p22(phox).

• Indicators of inflammation, including activation of NFkappaB and upregulation of vascular cell adhesion molecule-1 (VCAM-1) in aorta, and monocyte chemotactic protein-1 (MCP-1) in plasma, also were significantly increased in old rats.

• Supplementation with 0.2% (wt/wt) (R)-alpha-lipoic acid (LA) for 2 weeks caused a nonsignificant decrease in NADPH oxidase activity in aged aorta and a significant decrease in mRNA - but not protein - levels of NOX4 [oxidative stress indicator] and VCAM-1 [inflammation indicator].

• Furthermore, LA reversed the age-dependent changes in aortic SOD activity [oxidative stress indicator] and plasma MCP-1 levels [inflammation indicator].

Hence, vascular oxidative stress and inflammation increase with age and are ameliorated by alpha-lipoic acid supplementation.

[Note: for an overview of research on alpha-lipoic acid’s roles in energy production, metal chelation, antioxidant activity, glucose regulation, and more, see the Linus Pauling Institute’s Micronutrient Information Center - http://lpi.oregonstate.edu/infocenter/othernuts/la/]

Source: Annals of the New York Academy of Sciences, Aug 2010;1203:151-9. PMID: 20716298, by Li L, Smith A, Hagen TM, Frei B. Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing