ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

Omega-3 shows promise as stroke treatment

 
Print Page
Email Article

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms – Source: PLoS One, Sep 14, 2010

  [ 4 votes ]   [ Discuss This Article ]
By Thibaud Lebouvier, et al. • www.ProHealth.com • September 17, 2010


[Note: to read the full text of this article free, click HERE.  Lewy bodies/neurites are abnormal protein clumps that develop inside the nerve cells of Parkinson’s patients – both in the brain and, as this study of colon biopsies demonstrates, in the enteric nervous system (which directly controls the gastrointestinal system).]

Background: The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients.
 
The aims of the present research were to use routine colonoscopy biopsies:

1. To analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP) [tissue containing nerves, blood and lymphatic vessels supplying the mucous lining], and

2. To correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.

Methodology/Principal Findings: A total of 10 control and 29 PD patients divided into 3 groups according to disease duration were included. PD and GI symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively. Four biopsies were taken from the ascending and descending colon during the course of a total colonoscopy.

Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein, neurofilaments NF 220 kDa (NF) and tyrosine hydroxylase (TH).

The density of LN, labeled by anti-phosphorylated alpha-synuclein antibodies, was evaluated using a quantitative rating score.

Lewy pathology was apparent in the colonic biopsies from 21 patients and in none of the controls.

A decreased number of NF-immunoreactive neurons per ganglion was observed in the SMP of PD patients compared to controls.

The amount of LN in the ENS was inversely correlated with neuronal count and positively correlated with levodopa-unresponsive features and constipation.

Conclusion/Significance: Analysis of the ENS by routine colonoscopy biopsies:

• Is a useful tool for pre-mortem neuropathological diagnosis of PD,

• And also provides insight into the progression of motor and non-motor symptoms.

Source: PLoS One, Sep 14, 2010;5(9): e12728. DOI:10.1371/journal.pone.0012728, by Lebouvier T, Neunlist M, de varannes SB, Coron E, Brouard A, N’guyen JM, Chaumette T, Tasselli M, Paillusson S, flamand M, Galmiche JP, Damier P, Derkinderen P. Inserm, Nantes; Universite de Nantes; CHU Nantes, France. [Email: thibaud.lebouvier@univ-nantes.fr]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Safely Burn Away Body Fat Safely Burn Away Body Fat

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map