Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Benefits of Coconut Oil Are Undeniable

Acupuncture used in clinical settings reduced symptoms of menopause

How Awesome Is Ashwagandha?

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

Clinical trial demonstrates success of low FODMAP diet

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

Turmeric: The Spice of Life

What’s so Remarkable About Rosemary?

Vitamin nicotinamide riboside protects mice from diabetes complications

 
Print Page
Email Article

Is the mechanism of systemic immune activation in XMRV-positive CFS patients similar to that observed in HIV? – Source: 1st International XMRV Workshop Abstract Book, Sep 2010

  [ 15 votes ]   [ Discuss This Article ]
By Kenny De Meirleir, MD, PhD, et al. • www.ProHealth.com • September 22, 2010


Introduction: HIV-1 infection results in chronic activation of the immune system. It was suggested (Brenchley et al., Nature 2006) to occur through a breakdown of the mucosal barrier and stimulation of immune cells by microbial products.

CD14+ monocytes/macrophages secrete soluble CD14 (sCD14), which binds LPS and pro-inflammatory cytokines. In the study cited above it was shown that LPS directly stimulates sCD14 production in vivo.

Earlier our group reported that serum LPS is significantly higher in Chronic Fatigue Syndrome (CFS) patients compared to contact and non-contact controls.

Our hypothesis is that XMRV positive CFS patients also present with immune activation related to mucosal translocation in the gut.

Material & Methods: Fifteen XMRV positive CFS patients who fulfilled the Fukuda et al. criteria (1994) and matched controls were studied. The detection of XMRV was performed by LNCaP co-culture with PMCs as described by Lombardi et al. (2009).

We used commercially available ELISA’s to quantify levels of sCD14, C4a and cytokines. Stool IgA was determined by Diagnos-Techs, Inc (Tukwila, Washington, USA). Statistical analysis was performed using an ANOVA T-test.

Results: XMRV positive CFS patients showed statistically significantly (p<0.05) higher serum levels of sCD14, C4a, IL-8 and MIP1-beta. Stool IgA levels were extremely low (p<0.01) compared to those of healthy controls.*

Conclusion: Although it is too early to conclude that XMRV is a cause of CFS, the similarity with HIV-1 where microbial translocation is a cause of systemic immune activation is striking.

A study in rhesus macaques infected with XMRV showed infected CD4+ T cells in the gastrointestinal tract. The frequency of infected XMRV cells in the gastrointestinal tract in these macaques increased from acute to chronic infection (Sharma et al.). The data of our study along with the findings in XMRV infected macaques ask for [suggests?] confirmation by performing gastrointestinal biopsy studies in XMRV-positive CFS patients.

[* Note: to read the full text of the brief associated article including the statistical analysis table, click HERE.]

Source: 1st International XMRV Workshop Abstract Book, Abstract P_20, pg. 36; Reviews in Antiviral Therapy & Infectious Diseases,  Sep 2010; vol 8. By De Meirleir K, Metzger K, Fremont M, Roelant G. Vrije Universiteit Brussel, Medical physiology, Brussel; RED Laboratories, Science Department, Zellik; Protea Biopharma, Science Department, Brussel, Belgium.





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Dr Axe Bone Broth Proteins

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map