Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Depersonalization and Derealization From Chronic Lyme Disease and Its Coinfections: A perpetual ment...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Nutritional Strategies for Preventing Age-Related Vision Loss

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

How Essential Oils Can Help Improve Your Life

Clinically Studied Joint Relief Product for FM & ME/CFS

 
Print Page
Email Article

New drug blocks opioid/morphine's respiratory suppression but not pain relief potency – animal trials

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 6, 2010


A new drug called repinotan blocks the respiratory depressant effects of morphine-like opioid drugs - without altering their potent pain-relieving effects, according to a study published Oct 1 in Anesthesia & Analgesia.

If the promising results of animal studies are borne out by future research, then repinotan could become an important part of safe, effective pain control after surgery.

The researchers, led by Dr. Ulf Guenther, MD, at the University Hospital of Bonn, Germany, performed a series of experiments to see how repinotan influenced the effects of morphine.

Although morphine and related drugs (opioids) are highly effective in treating pain after surgery, they share a common characteristic: They decrease the drive to breathe. This is a potentially serious side effect that can limit the use of opioid drugs for pain control.

In the study, rats were given a morphine dose high enough to slow the breathing rate. When the animals were subsequently treated with repinotan:

• Their respiratory rate rapidly returned toward normal.

• At the same time, repinotan did not alter the pain-blocking effects of morphine.

This is especially important because, although other drugs are available to reverse the respiratory depressant effects of opioids, they also reverse the pain-relieving effects.

There were no serious cardiovascular side effects with repinotan, although it did cause a drop in blood pressure.

"For years, investigators have tried to develop an opioid that produced the profound analgesia of morphine, but without the effects on breathing rate," explains Anesthesia & Analgesia Editor-in-Chief Dr. Steven L. Shafer of Columbia University.
 
More recently, specific types of drugs have been developed that selectively reverse morphine-induced depression of breathing. Repinotan is the first drug of this type that has proven suitable for studies in humans.

"This is an incredibly exciting development in opioid pharmacology," Dr. Shafer adds.

"A drug that blocks the ability of opioids to suppress breathing, while not interfering with the pain relief, would be a huge advance in pain management and patient safety,” he says. “Unless the drug had other toxicities, such a drug would immediately become the standard of care for post-operative patients receiving opioids."

Source: International Anesthesia Research Society news release, Oct 5, 2010



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt Cocoa's Polyphenol Riches – All the Health Benefits without the Sugar, Calories and Guilt

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing