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Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: A case study in ME/CFS. – Source: Journal of Clinical Pathology, Oct 5, 2010

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By Eliana M Lacerda, et al. • • October 11, 2010

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a condition, the aetiology of which remains controversial, and there is still no consensus on its nature and determination. It has rarely been studied in post-mortem examinations, despite increasing evidence of abnormalities from neuroimaging studies.

Aim: To ascertain the feasibility of developing a national post-mortem ME/CFS tissue bank in the UK, to enhance studies on aetiology and pathogenesis, including cell and tissue abnormalities associated with the condition.

Methods: The case study was carried out combining qualitative methods, ie, key informant interviews, focus group discussions with people with ME/CFS, and a workshop with experts in ME/CFS or in tissue banking.

Results and conclusions: The study results suggest that the establishment of the post-mortem ME/CFS tissue bank is both desirable and feasible, and would be acceptable to the possible tissue donors, provided that some issues were explicitly addressed.

Source: Journal of Clinical Pathology, Oct 5, 2010. PMID: 20924033, by Lacerda EM, Nacul L, Pheby D, Shepherd C, Spencer P. London School of Hygiene & Tropical Medicine, EPH/NPHIRU/CFS/ME Observatory, London, UK. [Email:]

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