[Note: sudden cardiac death is a major cause of mortality involving abrupt loss of heartbeat/function that may or may not involve any heart disease. To read more about magnesium's role in heart rhythm and blood pressure regulation, see for example the Nutritional Magnesium Association's heart health archive.]
Background: Magnesium has antiarrhythmic properties in cellular and experimental models; however, its relation to sudden cardiac death (SCD) risk is unclear.
Objective: We prospectively examined the association between magnesium, as measured in diet and plasma, and risk of SCD.
Design: The analysis was conducted within the Nurses' Health Study. The association for magnesium intake was examined prospectively in 88,375 women who were free of disease in 1980.
Information on magnesium intake, other nutrients, and lifestyle factors was updated every 2–4 y through questionnaires, and 505 cases of sudden or arrhythmic death were documented over 26 y of follow-up.
For plasma magnesium, a nested case-control analysis including 99 SCD cases and 291 controls matched for age, ethnicity, smoking, and presence of cardiovascular disease was performed.
Results: After multivariable adjustment for confounders and potential intermediaries, the relative risk of SCD was significantly lower in women in the highest quartile compared with those in the lowest quartile of dietary (relative risk: 0.63; 95% CI: 0.44, 0.91) and plasma (relative risk: 0.23; 95% CI: 0.09, 0.60) magnesium. The linear inverse relation with SCD was strongest for plasma magnesium (P for trend = 0.003), in which each 0.25-mg/dL (1 SD) increment in plasma magnesium was associated with a 41% (95% CI: 15, 58%) lower risk of SCD.
Conclusions: In this prospective cohort of women, higher plasma concentrations and dietary magnesium intakes were associated with lower risks of SCD. If the observed association is causal, interventions directed at increasing dietary or plasma magnesium might lower the risk of SCD.
Source: American Journal of Clinical Nutrition, Nov 24, 2010. PMID: 21106914, by Chiuve SE, Korngold EC, Januzzi JL, Gantzer ML, Albert CM. Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. [Email: firstname.lastname@example.org]