Full Abstract Title: Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease.
Objective: To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models.
Design: Prospective cohort study.
Setting: Northern Manhattan, New York.
Participants: 1,130 elderly individuals free of cognitive impairment at baseline.
Main Outcome Measure: High-density lipoprotein cholesterol (HDL-C) levels.
Results: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). [A hazard ratio of 1.0 would indicate no difference in risk. The 0.4 ratio represents 60% less likelihood of developing Alzheimer’s or signs of impending AD.]
In addition, higher levels of total and non–HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype.
Conclusion: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
Source: Archives of Neurology, Dec 2010;67(12):1491-1497. doi:10.1001/archneurol.2010.297, by Reitz C, Tang M, Schupf N, Manly J, Mayeux R, Luchsinger JA. Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging, Departments of Neurology, Medicine, and Psychiatry, and Departments of Biostatistics and Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York.