ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Top Anti-Inflammatory Foods, Herbs, and Spices

Latent HIV may lurk in 'quiet' immune cells, research suggests

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Multiple sclerosis: pathological progression of the disease documented for the first time

Propolis - The Natural Antibiotic for MRSA, Candida, and More

Microbiome linked to type 1 diabetes

Omega-3 fatty acids, vitamin D may control brain serotonin, affecting behavior and psychiatric disor...

Lyme disease costs up to $1. 3 billion per year to treat, study finds

Common Allergy Medication May Be Effective In Starving and Killing the Bacteria That Causes Lyme Dis...

Link between inflammation and type 2 diabetes identified

 
Print Page
Email Article

Association between nonspecific skeletal pain and vitamin D deficiency – Source: International Journal of Rheumatic Diseases, Oct 2010

  [ 8 votes ]   [ Discuss This Article ]
By B Heidari, et al. • www.ProHealth.com • January 5, 2011


Background: Deficiency of vitamin D has been reported in patients with many types of musculoskeletal pain. The present study was designed to determine the association between serum 25-hydroxyvitamin D [25-(OH)D] deficiency and nonspecific skeletal pain.

Methods: A total of 276 patients with nonspecific skeletal pain at different regions of the skeletal system diagnosed as leg pain, widespread pain, arthralgia [joint pain], rib pain, back pain and fibromyalgia were compared with 202 matched controls with regard to mean serum 25-(OH)D level and 25-(OH)D deficiency.

Serum 25-(OH)D was measured by enzyme-linked immunosorbent assay method and levels < 20 ng/mL were considered as deficient. Nonparametric one-way analysis of variance, Kruskal Wallis and Wilcoxon tests were used for group comparisons. Multiple logistic regression analysis with calculation of adjusted odds ratio (OR) and 95% confidence interval (95% CI) were performed to determine associations.

Results: In patients with nonspecific skeletal pain the mean 25-(OH)D was significantly lower (P = 0.0001) [That is, the probability (P) that this association resulted by chance was less than 1 in 10,000] and the proportion of 25-(OH)D deficiency was significantly higher (63.4% vs. 36.1%, P = 0.0001) compared with controls.

There was a significantly positive association between 25-(OH)D deficiency and skeletal pain (OR = 2.94, 95% CI = 1.01–4.3, P = 0.0001). [Note: an odds ratio of 1.0 would have signified no greater odds of skeletal pain among those with a vitamin D deficiency. The OR of 2.94 indicates the deficient subjects were nearly 3 times more likely to have skeletal pain. And the probability (P) that this association resulted by chance is less than 1 in 10,000.]

The strength of association varied across the groups with:

• Strongest association observed with leg pain (OR = 7.4; 95% CI = 3.9–13.9, P = 0.0001) [Deficient subjects 7.4 times as likely to have leg pain.]

• Followed by arthralgia [joint pain] (OR = 3.9, 95% CI = 2.1–7.1, P = 0.0001)

• And widespread pain (OR = 2.8, 95% CI = 1.1–6.6, P = 0.020)

• But no association with back pain and fibromyalgia. [Presuming ‘widespread pain’ was considered mainly pain in bones/joints and FM pain typically muscle pain.]

There was a greater positive association in women compared with men (OR = 2.1, 95% CI = 1.1–4.3, P = 0.001).

Conclusion:

The results of this study indicate a positive association of vitamin D deficiency with a variety of nonspecific bone pain, particularly in women.

More studies with larger samples are required to confirm these findings. Increasing serum vitamin D to sufficient levels and longitudinal follow-up of patients may provide further evidence in relation to vitamin D deficiency and skeletal pain.

Source:
International Journal of Rheumatic Diseases, Oct 2010;13(4) pp 340-346. DOI: 10.1111/j.1756-185X.2010.01561.x, by Heidari B, Shirvani JS, Firouzjahi A, Heidari P, Hajian-tilake KO. Department of Medicine, Division of Rheumatology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. [Email: heidaribeh@yahoo.com]
 




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Vitamin D3 1000 IU Vitamin D3 1000 IU
Crucial nutrient for strong bones, heart and immune health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Preserving Cognitive Function with Aging Preserving Cognitive Function with Aging
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing