ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

List of diseases spread by deer tick grows, including malaria-like problems and potentially fatal en...

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

Lyme disease confirmed in humans from southern states

The Worst Foods to Eat When You're Sick, and the Best Ones

Teenager with stroke symptoms actually had Lyme disease

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from do...

World Famous Joint Relief Formula Enhanced by Modern Science

Scientists Reveal Quirky Feature of Lyme Disease Bacteria

Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges

 
Print Page
Email Article

"Administration of omega-3 fatty acids plus L-carnitine would improve ME/CFS symptomology" by supporting efficient mitochondrial function, groundbreaking study suggests

  [ 41 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 21, 2011


[Ed Note: Carnitine (L-carnitine) and its acyl esters (acylcarnitines) are essential compounds for the metabolism of fatty acids. Carnitine’s main function is to assist the transport and metabolism of fatty acids in the cells’ energy-generating mitochondria.]

Article:
Long-chain acylcarnitine deficiency in chronic fatigue syndrome patients. Potential involvement of altered carnitine palmitoyltransferase-I activity
– Source: Journal of Internal Medicine, Dec. 22, 2010

Authors: Stephanie E Reuter, Allan M Evans

Objective: The underlying etiology of chronic fatigue syndrome is currently unknown; however, in light of carnitine’s critical role in mitochondrial energy production, it has been suggested that chronic fatigue syndrome may be associated with altered carnitine homeostasis. This study was conducted to comparatively examine full endogenous carnitine profiles in chronic fatigue syndrome patients and healthy controls.

Design: A cross-sectional, observational study.

Setting and subjects: Forty-four patients with chronic fatigue syndrome and 49 age- and gender-matched healthy controls were recruited from the community and studied at the School of Pharmacy & Medical Sciences, University of South Australia.

Main outcome measures:  All participants completed a fatigue severity scale questionnaire and had a single fasting blood sample collected which was analyzed for L-carnitine and 35 individual acylcarnitine concentrations in plasma by LC-MS/MS.

Results:

• Chronic fatigue syndrome patients exhibited significantly altered concentrations of C8:1, C12DC, C14, C16:1, C18, C18:1, C18:2 and C18:1-OH acylcarnitines;

• Of particular note, oleyl-L-carnitine (C18:1) and linoleyl-L-carnitine (C18:2) were, on average, 30% to 40% lower in patients than controls (p<0.0001).

• Significant correlations between acylcarnitine concentrations and clinical symptomology were also demonstrated.

Conclusions:

It is proposed that this disturbance in carnitine homeostasis is a result of a reduction in carnitine palmitoyltransferase-I (CPT-I) activity, possibly due to the accumulation of omega-6 fatty acids previously observed in this patient population.

It is hypothesized that the administration of omega-3 fatty acids [rich in oily fish and fish and krill oils], and in combination with L-carnitine would increase CPT-I activity and improve chronic fatigue syndrome symptomology.

Source: Journal of Internal Medicine, Dec. 22, 2010. PMID: 21205027, by Reuter SE, Evans AM. School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia. [Email: stephanie.reuter@unisa.edu.au]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Acetyl L-Carnitine HCL by ProHealth Acetyl L-Carnitine HCL by ProHealth
Sharpen Mental Focus & Concentration
Arctic Select Krill Oil™ by ProHealth Arctic Select Krill Oil™ by ProHealth
Your Ultimate Source of Omega-3
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
SAD? Coping with Seasonal Affective Disorder
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing