ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

Motor Symptoms of Parkinson’s Stalled with Deep Brain Stimulation – Five Years In

  [ 5 votes ]   [ Discuss This Article ] • January 28, 2011

“Motor symptoms remained remarkably stable over time. There was no significant progression.”

Parkinson’s disease symptoms begin subtly and worsen as damage to certain brain cells continues. But an electrical stimulation device implanted deep in the brain and programmed remotely, along with medications, may provide some control of “motor symptoms” common to the disease, such as shaking, stiffness, and loss of muscle control.

What happens, however, if the drugs are stopped and the device is switched off after five years? Are the symptoms far worse than they were to start, as might be expected with a “progressive” degenerative disorder?

Surprisingly, no, says neurologist Michele Tagliati, MD, director of the Movement Disorders Program at Cedars-Sinai Medical Center in Los Angeles, and one of the nation’s leading experts in deep brain stimulation therapy.

He and colleagues at Mount Sinai School of Medicine, where he served until recently, evaluated several of their deep brain stimulation patients at one-year intervals: 21 patients at year one; 17 at year two; 14 at year three; 16 at year four; and nine at year five.

Part of their analysis – evaluating patients while their drugs temporarily were discontinued but brain stimulation continued – confirmed previous studies: Deep brain stimulation is an effective therapy for advanced Parkinson’s disease up to five years from implantation, although there is a gradual reduction in benefit over time.

This effectiveness decline usually is attributed to the disease’s unrelenting progression.

But the researchers also explored Parkinson’s natural progression in these patients by temporarily discontinuing both their drugs and brain stimulation, then comparing motor function at these yearly intervals with pre-treatment scores.

“In these patients who were effectively treated with DBS stimulation, we found that motor symptoms remained remarkably stable over time. There was no significant progression,” states Dr. Tagliati.

“Now we need to do larger studies to find out why,” he adds. “It may be, as some have suggested, that deep brain stimulation stabilizes the motor progression of the disease, although other studies indicate that Parkinson’s disease may just naturally stabilize after several years of progression.”

Unfortunately, he points out, “non-motor” symptoms, including depression, dementia and others, currently do not respond to deep brain stimulation and appear to continue to progress.

Dr. Tagliati, who leads an educational course on deep brain stimulator programming every year at the American Academy of Neurology meetings, has been studying the procedure for more than a decade, beginning several years before the device was approved as a therapy by the Food and Drug Administration.

He and his counterpart at the University of California, Los Angeles, Jeff M. Bronstein, MD, PhD, recently led a panel of international experts in developing a consensus on key issues related to the procedure for Parkinson’s disease. This document, with insight and guidance, was published in the Archives of Neurology.(1) And the new study was reported in the Nov 2010 International Journal of Neuroscience.(2)

Requirements for Success

“Providing the most effective therapy requires teamwork and the experience and expertise that come from working in a specialized center,” Dr. Taliati explains.

“It involves placing the device in precisely the right location, programming and fine-tuning the device, properly adjusting medications, studying many patients and outcomes, learning and teaching – all the activities found in an academic center.

“We’re looking forward to pursuing innovative research strategies in the near future. Although we know DBS can help many patients with Parkinson’s disease, there’s much more we need to learn. We can see that stimulation works but we don’t really know how it works.”

Decision to Use the Device & Typical Results

Most patients suffering from Parkinson’s disease first are treated with medication to improve levels of dopamine, a chemical lost when certain brain cells are damaged. But if drugs fail to provide adequate symptom control or if patients have unmanageable side effects, deep brain stimulation may be an option.
The device consists of electrical leads implanted in the brain and a stimulator located near the collarbone. The stimulator is programmed with a remote, handheld controller to block abnormal nerve signals that cause uncontrollable muscle activity.

• This procedure does not replace drugs but it often allows their dosage to be reduced; the combination provides better muscle and movement control than drugs alone.

• Motor function improvements range from 27% to 72% within a year of deep brain stimulation surgery, according to earlier research.

1. Archives of Neurology, Oct 2010, “Deep Brain Stimulation for Parkinson Disease”

2. International Journal of Neuroscience, Nov 2010, “Lack of Motor Symptoms Progression in Parkinson’s Disease Patients With Long-Term Bilateral Subthalamic Deep Brain Stimulation.”

Source: Cedars Sinai Medical Center news release, Jan 18, 2011

Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Complete and Natural Menopause Relief Complete and Natural Menopause Relief

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map