ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Reverse Mitochondrial Damage

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

CoQ10: The Longevity Factor

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc(Min/+) Mouse - Source: Nutrition and Cancer, Mar 2011

  [ 17 votes ]   [ Discuss This Article ]
By EA Murphy, et al. • www.ProHealth.com • March 16, 2011


[Note: quercetin is a plant-derived ‘flavonoid’ chemical (plentiful in green & black tea, red wine & grapes, onions, apples, broccoli, etc.) and studies indicate it supports anti-inflammatory and antioxidant processes, according to the American Cancer Society.]

Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer; however, experimental studies in rodents are limited.

Macrophages play a role in tumorigenesis [tumor formation], but the effects of quercetin on macrophage infiltration in colon cancer is unknown. [When T cells recognize tumor cells, they activate macrophages whose job it is to engulf and digest cells in the local area. Thus macrophage activation is a measure of tumor cell activity.]

We examined the effects of quercetin on intestinal polyp multiplicity and macrophage number in Apc(Min/+) mice. [A special mutant mouse strain that develops colon cancer.]

Apc(Min/+) mice were assigned to placebo or quercetin (n = 8/group) groups.

Mice were given a placebo or quercetin (0.02%) diet from 4 to 20 weeks of age, after which:

• Intestines were analyzed:

- For polyp number and size in the small intestine (Sections 1-4) and colon (Section 5)

- And for macrophage number in the small intestine (Sections 1 and 3).

• Spleen weight was determined as a marker of systemic inflammation.

Quercetin decreased total intestinal polyps by 67% (P < 0.05).

Specifically, quercetin reduced intestinal polyps in categories >2 mm (69%) and 1-2 mm (79%; P < 0.05), and in Sections 2 (75%), 3 (80%), and 4 (79%; P < 0.05).

Quercetin also decreased macrophage number in Sections 1 (57%) and 3 (81%), and spleen weight (P < 0.05).

These data suggest that quercetin can reduce polyp number and size distribution in the Apc(Min/+) mouse and that these effects may be related to a reduction in macrophage infiltration.

Source: Nutrition and Cancer, Mar 2011;1(1). PMID: 21391122, by Murphy EA, Davis JM, McClellan JL, Carmichael MD. Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Quercetin / Bromelain Complex Quercetin / Bromelain Complex
Balances Histamine Levels Naturally
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing