ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

CoQ10: The Longevity Factor

Is Homocysteine Making You Sick?

VIDEO: Beautiful Clouds - Relaxation and Meditation

Magnesium: Widespread Deficiency with Deadly Consequences

 
Print Page
Email Article

Association of Duration and Severity of Diabetes Mellitus with Mild Cognitive Impairment - Source: Archives of Neurology, August 2008

  [ Not Yet Rated ]   [ Discuss This Article ]
By RO Roberts, et al. • www.ProHealth.com • August 12, 2008


[Note: mild cognitive impairment is considered an intermediate stage between normal cognitive aging and dementias such as Alzheimer’s.]

Background: It remains unknown whether diabetes mellitus (DM) is a risk factor for mild cognitive impairment (MCI).

Objective: To investigate the association of DM with MCI using a population-based case-control design.

Design: Population-based case-control study.

Setting: Academic research.

Participants: Our study was conducted, among subjects aged 70 to 89 years on October 1, 2004, who were randomly selected from the Olmsted County (Minnesota) population.

Main Outcome Measure: We administered to all participants a neurologic examination, the Clinical Dementia Rating Scale, and a neuropsychological evaluation (including 9 tests in 4 cognitive domains) to diagnose normal cognition, MCI, or dementia. We assessed history of DM, DM treatment, and DM complications by interview, and we measured fasting blood glucose levels. History of DM was also confirmed using a medical records linkage system.

Results: We compared 329 subjects having MCI with 1,640 subjects free of MCI and dementia.

The frequency of DM was similar in subjects with MCI (20.1%) and in subjects without MCI (17.7%) (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.85-1.57).

However, MCI was associated with:

  • Onset of DM before age 65 years (OR, 2.20; 95% CI, 1.29-3.73), [an OR – “odds ratio” – of 1.0 would mean no association between onset of diabetes before age 65 and having mild cognitive impairment. In this case the statistics produced an odds ratio of 2.2, meaning MCI was more than twice as likely if diabetes developed before age 65.
  • DM duration of 10 years or longer (OR, 1.76; 95% CI, 1.16-2.68),
  • Treatment with insulin (OR, 2.01; 95% CI, 1.22-3.31),
  • And the presence of DM complications (OR, 1.80; 95% CI, 1.13-2.89) after adjustment for age, sex, and education. Analyses using alternative definitions of DM yielded consistent findings.

Conclusion: These findings suggest an association of MCI with earlier onset, longer duration, and greater severity of DM.

Source: Archives of Neurology, August 2008;65(8):1066-1073. by Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pantratz VS, Boeve BF, Vella A, Rocca WA, Petersen RC. Divisions of Epidemiology, Biostatistics, Health Sciences Research, Psychiatry and Psychology, Neurology, and Endocrinology, Department of Medicine, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing