[Note: to read the full text of this free access article, click HERE. See also the article indicating early evidence of XMRV in these intravenously infected animals became “undetectable in blood” after about a month but than reactivated 9 months later, suggesting it has the potential to be chronic: “Infection, viral dissemination and antibody responses of Rhesus macaques exposed to the human gammaretrovirus XMRV.”]
Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission.
We established a model of infection in rhesus macaques inoculated with XMRV.
In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages.
• XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells.
• In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag.
The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously, suggests the potential for sexual transmission for XMRV.
Source: Advances in Virology, May 25, 2011. Sharma P, Rogers K, Suppiah S, Molinaro RJ, Onlamoon N, Hackett J Jr., Schochetman G, Klein ER, Silverman R, Villinger F. Division of Pathology, Yerkes National Primate Research Center, Emory University; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia; Abbott Diagnostics, Emerging Pathogens and Virus Discovery, Abbott Park, Illinois; Glickman Urological and Kidney Institute and Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.