ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Will Gene Variant Discovery Explain Fibromyalgia?

  [ 44 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 17, 2011


The whole-genome sequencing of 14-year-old California twins with a mystery illness, and of their parents, brother, and grandparents, produced an important discovery with potentially far-reaching implications.

As reported June 15 in Science Translational Medicine(1) and by the National Public Radio Health Blog(2), the twins had a condition termed "DRD" (dopa-responsive dystonia), meaning they had "cerebral palsy-like" spasms thought to result from a deficiency of the neurotransmitter dopamine, which was helped by low doses of the Parkinson’s disease drug L-dopa.

The family’s whole-genome sequencing indicated that the twins had received a double dose of a gene variant (mutation) – one from their father's side, and one from their mother's side – that caused them to have low levels not just of dopamine but of the neurotransmitters serotonin and noradrenalin.

When their neurologist at Children’s Hospital in San Diego decided that in addition to L-dopa they should try supplementing the twins with 5-HTP (5-Hydroxy L-Tryptophan, a precursor that the body uses in serotonin production) their physical condition improved to a remarkable degree. 

Where Does Fibromyalgia Come In?
 
It turns out that there is a pattern of known fibromyalgia symptoms in the mother’s family (FM affects predominantly females), which could well be linked to the single copy of the gene variant that they carry. The researchers hypothesize that this gene variant could help explain the positive response of some fibromyalgia patients to SSRI anti-depressants, which work by raising serotonin levels.

“If that hypothesis pans out,” the NPR blog comments, “it would suggest that rare genetic disorders such as DRD are just the most dramatic manifestation – in people who inherit a double dose of certain gene variants – of much more common disorders such as fibromyalgia among people who have a single copy of the mutation.”

Discovery Was a Lucky Break

The twins’ father works for a biotech company that makes DNA sequencing machines, and was able to convince the pioneering researchers in whole-genome sequencing at Baylor College of Medicine to take on the family genome-sequencing project.

So is it only a matter of time before they or other cutting edge gene hunters will mount further studies of this potential “fibromyalgia variant” to see what it might reveal?

______

Sources:

1. “Whole-Genome Sequencing for Optimized Patient Management,” Matthew Banibridge, et al. Science Translational Medicine, June 15, 2011

2. “Genome Maps Solve Medical Mystery for California Twins,” by Richard Knox. NPR Health Blog, June 16, 2011




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg 5-HTP Extra Strength 200mg Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
5-HTP (5-Hydroxy L-Tryptophan) 5-HTP (5-Hydroxy L-Tryptophan)
Increase Serotonin Levels Naturally
5-HTP Extra Strength 200mg 5-HTP Extra Strength 200mg
Increase Serotonin Levels Naturally

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map