Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Essential Oils - How and Where to Use Them

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

SURVEY: What Is Your Diagnosis?

The Link Between Vitamin C And Optimal Immunity

The Amazing Health Benefits of Dark Chocolate

Liposomes Deliver Optimal Nutrient Absorption

Why Does Your Nose Run When It's Cold Outside?

How Your Mitochondria Influence Your Health

 
Print Page
Email Article

Lyme Bug Invades Lymph Nodes & Rewires Their Immune Response, UC Davis Researchers Find

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 22, 2011


B. burgdorferi destroys the distinct architecture of the lymph node that would enable it to function normally

Groundbreaking research by immunologists at University of California Davis has uncovered a key to Borrelia burgdorferi’s ability to elude the body’s immune defense system.

As they report in the June issue of PLoS Pathogens, the findings of their study in mice “suggest for the first time that B. burgdorferi, the bacteria that cause Lyme disease in people, dogs and wildlife, have developed a novel strategy for subverting the immune response of the animals they infect.”

Swollen lymph nodes, or lymphadenopathy, is one of the hallmarks of Lyme disease, although it has been unclear why this occurs or how it affects the course of the disease, according to lead author Nicole Baumgarth, DVM, PhD, an authority on immune responses at the UC Davis Center for Comparative Medicine.

So the team set out to explore in mice the mechanisms that cause the enlarged lymph nodes and to determine the nature of the resulting immune response. This is what they found:

• When mice were infected with B. burgdorferi, the live spirochetes accumulated in the animals’ lymph nodes.

• The lymph nodes responded with a strong, rapid accumulation of B cells - white blood cells that produce antibodies to fight infections.

• But at the same time, the presence of B. burgdorferi caused the destruction of the distinct architecture of the lymph node that usually helps it to function normally.

• Therefore, while B cells accumulated in large numbers and made some specific antibodies against B. burgdorferi, they did not form “germinal centers” - structures that are needed for the generation of highly functional and long-lived antibody responses.

“Overall, these findings suggest that B. burgdorferi hinder the immune system from generating a response that is fully functional and that can persist and protect after repeat infections,” Dr. Baumgarth said.

“Thus, the study might explain why people living in endemic areas can be repeatedly infected with these disease-causing spirochetes.”

(And perhaps will lead to an understanding of so-called “persistent Lyme disease” or “post-treatment Lyme syndrome,” and improved strategies for combating these problems.)

While Lyme disease occurs mainly in the Northeast and Upper Midwest/Great Lakes area, it is present on the West Coast as well, and the western black-legged tick, the main carrier of Lyme disease in the western US, has been found in 56 of California's 58 counties, according to the California Department of Public Health.

Sources: University of California Davis news release, June 8, 2011, and cited article, “Lymphoadenopathy during Lyme Borreliosis Is Caused by Spirochete Migration-Induced Specific B Cell Activation.”




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Live Without Anxiety or Stress
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing