ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Dietary Flavanols Reverse Age-Related Memory Decline

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

Discovery of 'stop hurting' antibody foreshadows pain therapies to come

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 8, 2011


"I'm excited about where these findings could take us in terms of eventually developing a new type of analgesic for people who suffer from chronic pain."Prof Stephen McMahon, King’s College London

Breakthrough research identifying the molecule responsible for making sunburn hurt (and an antibody that makes it stop hurting) has produced a juicy new target for development of therapies to treat inflammatory pain.

The molecule, known as “CXCL5,” is part of a family of proteins in the body called chemokines (responsible for issuing chemical ‘orders’), which recruit inflammatory immune cells to the injured tissue, triggering pain and tenderness.

The study, by a pain research team led by Prof Stephen McMahon and Dr. David Bennett at King’s College London, was the first to reveal this chemokine’s role in mediating pain. (See "CXCL5 Mediates UVB Irradiation-Induced Pain,” Jul 7, 2011, Science Translational Medicine.)

The study started by exposing patches of skin in healthy subjects to UVB irradiation, creating small areas of sunburn.

• The treated skin became tender over the following hours, with peak sensory change one to two days later. At this peak the researchers took small biopsies of the affected skin and analyzed the tissue for hundreds of pain mediators.
 
• They found that several of these mediators were over-expressed, so they then examined the biology of these factors in rats to find out whether they were likely to be responsible for driving the pain in the sunburned skin.
 
• The mediator CXCL5 was significantly over-expressed in the human biopsies and the biology of this chemokine in rats, which suggests it is responsible for a significant amount of sensitivity in the sunburn.

Further tests carried out on the rats showed that a neutralizing antibody targeting CXCL5 significantly reduced the sensitivity to pain caused by the UVB irradiation.

“These findings have shown for the first time the important role of this particular molecule in controlling pain from exposure to UVB irradiation,” Prof McMahon says. “But this study isn’t just about sunburn - we hope that we have identified a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis [bladder pain].”
 
”I’m excited about where these findings could take us in terms of eventually developing a new type of analgesic for people who suffer from chronic pain.”
 
Reversing the Animal-to-Human Research Paradigm

“Traditionally scientists have first studied the biology of diseases in animal models to identify mechanisms relevant to creating that state, but this often does not translate into effective treatments in the clinic,” Dr. Bennett points out. 

“What we have done is reverse this traditional method by identifying putative mediators in humans first, and then exploring this further in rats.

“This enabled us to see that the rats’ response to these pain mediators closely parallel those occurring in humans and identify mechanisms of action in the preclinical studies.
 
“We intend to extend this approach to other types of pain and in particular to study patients suffering from chronic pain with the hope that this will speed up the process of turning science into effective treatments for patients.

“Improving healthcare by translating research more rapidly into clinical practice in this way is at the heart of our Academic Health Sciences Centre, King’s Health Partners.”

The research was funded by the Wellcome Trust (as part of the London Pain Consortium), and the Biotechnology and Biological Sciences Research Council.
____

Source: King’s College London press release, Jul 7, 2011



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing