ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Benefits of Coconut Oil Are Undeniable

Acupuncture used in clinical settings reduced symptoms of menopause

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

How Awesome Is Ashwagandha?

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

Clinical trial demonstrates success of low FODMAP diet

Turmeric: The Spice of Life

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

What’s so Remarkable About Rosemary?

Vitamin nicotinamide riboside protects mice from diabetes complications

 
Print Page
Email Article

Discovery of 'stop hurting' antibody foreshadows pain therapies to come

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 8, 2011


"I'm excited about where these findings could take us in terms of eventually developing a new type of analgesic for people who suffer from chronic pain."Prof Stephen McMahon, King’s College London

Breakthrough research identifying the molecule responsible for making sunburn hurt (and an antibody that makes it stop hurting) has produced a juicy new target for development of therapies to treat inflammatory pain.

The molecule, known as “CXCL5,” is part of a family of proteins in the body called chemokines (responsible for issuing chemical ‘orders’), which recruit inflammatory immune cells to the injured tissue, triggering pain and tenderness.

The study, by a pain research team led by Prof Stephen McMahon and Dr. David Bennett at King’s College London, was the first to reveal this chemokine’s role in mediating pain. (See "CXCL5 Mediates UVB Irradiation-Induced Pain,” Jul 7, 2011, Science Translational Medicine.)

The study started by exposing patches of skin in healthy subjects to UVB irradiation, creating small areas of sunburn.

• The treated skin became tender over the following hours, with peak sensory change one to two days later. At this peak the researchers took small biopsies of the affected skin and analyzed the tissue for hundreds of pain mediators.
 
• They found that several of these mediators were over-expressed, so they then examined the biology of these factors in rats to find out whether they were likely to be responsible for driving the pain in the sunburned skin.
 
• The mediator CXCL5 was significantly over-expressed in the human biopsies and the biology of this chemokine in rats, which suggests it is responsible for a significant amount of sensitivity in the sunburn.

Further tests carried out on the rats showed that a neutralizing antibody targeting CXCL5 significantly reduced the sensitivity to pain caused by the UVB irradiation.

“These findings have shown for the first time the important role of this particular molecule in controlling pain from exposure to UVB irradiation,” Prof McMahon says. “But this study isn’t just about sunburn - we hope that we have identified a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis [bladder pain].”
 
”I’m excited about where these findings could take us in terms of eventually developing a new type of analgesic for people who suffer from chronic pain.”
 
Reversing the Animal-to-Human Research Paradigm

“Traditionally scientists have first studied the biology of diseases in animal models to identify mechanisms relevant to creating that state, but this often does not translate into effective treatments in the clinic,” Dr. Bennett points out. 

“What we have done is reverse this traditional method by identifying putative mediators in humans first, and then exploring this further in rats.

“This enabled us to see that the rats’ response to these pain mediators closely parallel those occurring in humans and identify mechanisms of action in the preclinical studies.
 
“We intend to extend this approach to other types of pain and in particular to study patients suffering from chronic pain with the hope that this will speed up the process of turning science into effective treatments for patients.

“Improving healthcare by translating research more rapidly into clinical practice in this way is at the heart of our Academic Health Sciences Centre, King’s Health Partners.”

The research was funded by the Wellcome Trust (as part of the London Pain Consortium), and the Biotechnology and Biological Sciences Research Council.
____

Source: King’s College London press release, Jul 7, 2011




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Dr Axe Bone Broth Proteins

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
How I Found My Long-Lost Energy How I Found My Long-Lost Energy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map