ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

In the mind or in the brain? Scientific evidence for central sensitization in chronic fatigue syndrome – Source: European Journal of Clinical Investigation, July 2011

  [ 7 votes ]   [ 2 Comments ]
By Jo Nijs, Mira Meeus, et al. • www.ProHealth.com • July 19, 2011


Central sensitization entails several top-down and bottom-up mechanisms, all contributing to the hyper-responsiveness of the central nervous system to a variety of inputs.

In the late nineties, it was first hypothesized that chronic fatigue syndrome (CFS) is characterized by hypersensitivity of the central nervous system (i.e. central sensitization). Since then, several studies have examined central sensitization in patients with CFS. The present paper provides an overview of such studies.

Various studies showed generalized hyperalgesia in CFS for a variety of sensory stimuli, including electrical stimulation, mechanical pressure, heat and histamine.

Various tissues are affected by generalized hyperalgesia: the skin, muscle tissue, and the lungs.

Generalized hyperalgesia in CFS is augmented, rather than decreased, following various types of stressors like exercise and noxious heat pain.

Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed.

The observation of central sensitization in CFS is in line with our current understanding of CFS. The presence of central sensitization in CFS corroborates with:

• The presence of several psychological influences on the illness,

• The presence of infectious agents and immune dysfunctions,

• And the dysfunctional hypothalamus pituitary adrenal-axis as seen in these severely debilitated patients.

Source: European Journal of Clinical Investigation, July 2011. DOI: 10.1111/j.1365-2362.2011.02575.x, by Nijs J, Meeus M, Van Oosterwijck J, Ickmans K, Moorkens G, Hans G, De Clerck LS. Department of Human Physiology, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel; Division of Musculoskeletal Physiotherapy, Department of Health Care Sciences, Artesis University College Antwerp, Belgium. [Email: Jo.Nijs@vub.ac.be]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

I read the article
Posted by: Juloo
Jul 19, 2011
I understood most of it but the following line...could someone translate: "Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed."
Reply Reply

 
Effect or Cause
Posted by: IanH
Jul 20, 2011
This is in line with the theory proposed by Prof. Yunus "Central Sensitivity Illness".

It describes the EFFECT of the illness on the nervous system. Most evidence is now for an immunological cause. The immunolgical cause in turn predicts the sensitisation via neuropeptide upregulation.

 

 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map