Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Decreased levels of vitamin D associated with reduced methylation in African American teens

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

7 Natural Ways to Prevent Diabetes

8 Hacks to Slash Medication Costs

New Study Shows Optimized Curcumin Stops Inflammation

Relief from Common Digestive Distress

What Foods Can Help Fight the Risk of Chronic Inflammation?

Block The Vascular Origins Of Cognitive Decline

SURVEY: Should Opioids Be Restricted for Chronic Illness?

 
Print Page
Email Article

In the mind or in the brain? Scientific evidence for central sensitization in chronic fatigue syndrome – Source: European Journal of Clinical Investigation, July 2011

  [ 7 votes ]   [ 2 Comments ]
By Jo Nijs, Mira Meeus, et al. • www.ProHealth.com • July 19, 2011


Central sensitization entails several top-down and bottom-up mechanisms, all contributing to the hyper-responsiveness of the central nervous system to a variety of inputs.

In the late nineties, it was first hypothesized that chronic fatigue syndrome (CFS) is characterized by hypersensitivity of the central nervous system (i.e. central sensitization). Since then, several studies have examined central sensitization in patients with CFS. The present paper provides an overview of such studies.

Various studies showed generalized hyperalgesia in CFS for a variety of sensory stimuli, including electrical stimulation, mechanical pressure, heat and histamine.

Various tissues are affected by generalized hyperalgesia: the skin, muscle tissue, and the lungs.

Generalized hyperalgesia in CFS is augmented, rather than decreased, following various types of stressors like exercise and noxious heat pain.

Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed.

The observation of central sensitization in CFS is in line with our current understanding of CFS. The presence of central sensitization in CFS corroborates with:

• The presence of several psychological influences on the illness,

• The presence of infectious agents and immune dysfunctions,

• And the dysfunctional hypothalamus pituitary adrenal-axis as seen in these severely debilitated patients.

Source: European Journal of Clinical Investigation, July 2011. DOI: 10.1111/j.1365-2362.2011.02575.x, by Nijs J, Meeus M, Van Oosterwijck J, Ickmans K, Moorkens G, Hans G, De Clerck LS. Department of Human Physiology, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel; Division of Musculoskeletal Physiotherapy, Department of Health Care Sciences, Artesis University College Antwerp, Belgium. [Email: Jo.Nijs@vub.ac.be]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

I read the article
Posted by: Juloo
Jul 19, 2011
I understood most of it but the following line...could someone translate: "Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed."
Reply Reply

 
Effect or Cause
Posted by: IanH
Jul 20, 2011
This is in line with the theory proposed by Prof. Yunus "Central Sensitivity Illness".

It describes the EFFECT of the illness on the nervous system. Most evidence is now for an immunological cause. The immunolgical cause in turn predicts the sensitisation via neuropeptide upregulation.

 

 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map