ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Reverse Mitochondrial Damage

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

CoQ10: The Longevity Factor

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

CDC study may link expression of two genes to CFS: Relate to learning/memory and sleep-wake cycle

  [ 17 votes ]   [ 1 Comment ]
www.ProHealth.com • September 14, 2011


Article:
Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome
– Source: Neuropsychobiology, Sep 9, 2011

By Alicia K Smith, et al.

[Note: to read the full text of this important article click HERE.]

Background: There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS).

While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored.

We employed a novel convergent functional genomics approach that incorporates the findings from single-nucleotide polymorphism (SNP) and mRNA expression studies to identify associations between CFS and novel candidate genes for further investigation.

Methods:

We evaluated 116,204 SNPs in 40 CFS and 40 nonfatigued control subjects along with mRNA expression of 20,160 genes in a subset of these subjects (35 CFS subjects and 27 controls) derived from a population-based study.

Results:

• Sixty-five SNPs were nominally associated with CFS (p ! 0.001),

• And 165 genes were differentially expressed ( 6 4-fold; p ^0.05) in peripheral blood mononuclear cells of CFS subjects.

• Two genes, glutamate receptor, ionotropic, kinase 2 (GRIK2) and neuronal PAS domain protein 2 (NPAS2), were identified by both SNP and gene expression analyses.

• Subjects with the G allele of rs2247215 (GRIK2) were more likely to have CFS (p = 0.0005),

• And CFS subjects showed decreased GRIK2 expression (10-fold; p = 0.015).

• Subjects with the T allele of rs356653 (NPAS2) were more likely to have CFS (p = 0.0007),

• And NPAS2 expression was increased (10-fold; p = 0.027) in those with CFS.

Conclusion:
Using an integrated genomic strategy, this study:

• Suggests a possible role for genes involved in glutamatergic neurotransmission [important for learning and memory] and circadian rhythm [wake sleep cycle] in CFS

• And supports further study of novel candidate genes in independent populations of CFS subjects.

Source: Neuropsychobiology, Sep 9, 2011. 64:183–194. DOI: 10.1159/000326692, by Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS. Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia; Z-Tech Corporation, an ICF International Company at NCTR/Food and Drug Administration, Jefferson, Arkansas, USA.




Please Discuss This Article:   Post a Comment 

2005 Reeves definition used. not the Fukuda
Posted by: Kelly Latta
Sep 14, 2011
This study very specifically states that they used the 2005 Reeves definition not the original 1994 Fukuda definition. "...CFS was diagnosed using the criteria of the 1994 International Research Case Definition [24] as recommended by the International CFS study group [25] and currently used by the CDC [23]. The reference paper for #23 under "currently used by the CDC" is the Reeves definition. #23 - 23 Reeves WC, Wagner D, Nisenbaum R, Jones JF, Gurbaxani B, Solomon L, Papanicolaou DA, Unger ER, Vernon SD, Heim C: Chronic fatigue syndrome – a clinically empirical approach to its definition and study. BMC Med 2005; 3: 19.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing