Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Nature Heals

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

 
Print Page
Email Article

CDC study may link expression of two genes to CFS: Relate to learning/memory and sleep-wake cycle

  [ 17 votes ]   [ 1 Comment ]
www.ProHealth.com • September 14, 2011


Article:
Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome
– Source: Neuropsychobiology, Sep 9, 2011

By Alicia K Smith, et al.

[Note: to read the full text of this important article click HERE.]

Background: There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS).

While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored.

We employed a novel convergent functional genomics approach that incorporates the findings from single-nucleotide polymorphism (SNP) and mRNA expression studies to identify associations between CFS and novel candidate genes for further investigation.

Methods:

We evaluated 116,204 SNPs in 40 CFS and 40 nonfatigued control subjects along with mRNA expression of 20,160 genes in a subset of these subjects (35 CFS subjects and 27 controls) derived from a population-based study.

Results:

• Sixty-five SNPs were nominally associated with CFS (p ! 0.001),

• And 165 genes were differentially expressed ( 6 4-fold; p ^0.05) in peripheral blood mononuclear cells of CFS subjects.

• Two genes, glutamate receptor, ionotropic, kinase 2 (GRIK2) and neuronal PAS domain protein 2 (NPAS2), were identified by both SNP and gene expression analyses.

• Subjects with the G allele of rs2247215 (GRIK2) were more likely to have CFS (p = 0.0005),

• And CFS subjects showed decreased GRIK2 expression (10-fold; p = 0.015).

• Subjects with the T allele of rs356653 (NPAS2) were more likely to have CFS (p = 0.0007),

• And NPAS2 expression was increased (10-fold; p = 0.027) in those with CFS.

Conclusion:
Using an integrated genomic strategy, this study:

• Suggests a possible role for genes involved in glutamatergic neurotransmission [important for learning and memory] and circadian rhythm [wake sleep cycle] in CFS

• And supports further study of novel candidate genes in independent populations of CFS subjects.

Source: Neuropsychobiology, Sep 9, 2011. 64:183–194. DOI: 10.1159/000326692, by Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS. Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia; Z-Tech Corporation, an ICF International Company at NCTR/Food and Drug Administration, Jefferson, Arkansas, USA.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

2005 Reeves definition used. not the Fukuda
Posted by: Kelly Latta
Sep 14, 2011
This study very specifically states that they used the 2005 Reeves definition not the original 1994 Fukuda definition. "...CFS was diagnosed using the criteria of the 1994 International Research Case Definition [24] as recommended by the International CFS study group [25] and currently used by the CDC [23]. The reference paper for #23 under "currently used by the CDC" is the Reeves definition. #23 - 23 Reeves WC, Wagner D, Nisenbaum R, Jones JF, Gurbaxani B, Solomon L, Papanicolaou DA, Unger ER, Vernon SD, Heim C: Chronic fatigue syndrome – a clinically empirical approach to its definition and study. BMC Med 2005; 3: 19.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map