ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Magnesium Protects Against Stroke, Heart Disease and Diabetes

 
Print Page
Email Article

Reduced insular gamma-aminobutyric acid [GABA] in fibromyalgia – Source: Arthritis & Rheumatism, Sep 13, 2011

  [ 58 votes ]   [ Discuss This Article ]
By BR Foerster, et al. • www.ProHealth.com • September 14, 2011


Objective: Recent scientific findings have re-invigorated interest in examining the role of gamma-aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions.

Decreased inhibitory neurotransmission is a proposed mechanism in the pathophysiology of chronic pain syndromes such as fibromyalgia (FM).

The purpose of this study was to test the hypothesis that decreased levels of insular and anterior cingulate GABA would be present in FM patients and the concentration of this neurotransmitter would be correlated with pressure pain thresholds.

Methods: Sixteen FM patients and 17 age- and sex-matched healthy controls underwent pressure pain testing and a 3 Tesla proton magnetic resonance spectroscopy session in which the right anterior insula, right posterior insula, anterior cingulate and occipital cortex were examined at rest.

Results:


Compared with healthy controls, FM patients had significantly lower levels of GABA in the right anterior insula (mean±SD 1.17±0.24 arbitrary institutional units versus 1.42±0.32 arbitrary institutional units; p=0.016).

There was a trend toward increased GABA levels in the anterior cingulate of FM patients versus healthy controls (p=0.06).

No significant differences between groups were detected in the posterior insula or occipital cortex (p>0.05 for all comparisons).

Within the right posterior insula, higher levels of GABA were positively correlated with pressure pain thresholds for the FM patients (rho=0.63; p=0.02).

Conclusion:
Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes.

Source: Arthritis & Rheumatism, Sep 13, 2011. PMID: 21913179, by Foerster BR, Petrou M, Edden RA, Phd PC, Schmidt-Wilcke T, Lowe SE, Phd SE, Clauw DJ, Harris RE. Department of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ann Arbor VA Healthcare System, Ann Arbor, Michigan. [Email: compfun@umich.edu]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® L-Theanine Calm-Plex with GABA & 5-HTP (Suntheanine®)

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
L-Theanine Calm-Plex with GABA & 5-HTP (Suntheanine®) L-Theanine Calm-Plex with GABA & 5-HTP (Suntheanine®)
Synergistic Formula Enhances Mood & Well-being
GABA GABA
Natural Neurotransmitter Helps Reduce Stress
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map