ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Reduced insular gamma-aminobutyric acid [GABA] in fibromyalgia – Source: Arthritis & Rheumatism, Sep 13, 2011

  [ 58 votes ]   [ Post a Comment ]
By BR Foerster, et al. • www.ProHealth.com • September 14, 2011

previous article next article

Objective: Recent scientific findings have re-invigorated interest in examining the role of gamma-aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions.

Decreased inhibitory neurotransmission is a proposed mechanism in the pathophysiology of chronic pain syndromes such as fibromyalgia (FM).

The purpose of this study was to test the hypothesis that decreased levels of insular and anterior cingulate GABA would be present in FM patients and the concentration of this neurotransmitter would be correlated with pressure pain thresholds.

Methods: Sixteen FM patients and 17 age- and sex-matched healthy controls underwent pressure pain testing and a 3 Tesla proton magnetic resonance spectroscopy session in which the right anterior insula, right posterior insula, anterior cingulate and occipital cortex were examined at rest.

Results:


Compared with healthy controls, FM patients had significantly lower levels of GABA in the right anterior insula (mean±SD 1.17±0.24 arbitrary institutional units versus 1.42±0.32 arbitrary institutional units; p=0.016).

There was a trend toward increased GABA levels in the anterior cingulate of FM patients versus healthy controls (p=0.06).

No significant differences between groups were detected in the posterior insula or occipital cortex (p>0.05 for all comparisons).

Within the right posterior insula, higher levels of GABA were positively correlated with pressure pain thresholds for the FM patients (rho=0.63; p=0.02).

Conclusion:
Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes.

Source: Arthritis & Rheumatism, Sep 13, 2011. PMID: 21913179, by Foerster BR, Petrou M, Edden RA, Phd PC, Schmidt-Wilcke T, Lowe SE, Phd SE, Clauw DJ, Harris RE. Department of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ann Arbor VA Healthcare System, Ann Arbor, Michigan. [Email: compfun@umich.edu]



previous article
  Rating 3.7 (58 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel sy... [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing