ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

New Option For Chronic Fatigue Syndrome

How Lipoic Acid Preserves Critical Mitochondrial Function

Living Longer, Healthier Lives with Resveratrol

Iodine: The Forgotten Medicine

Stop Bacteria With Nature's Antibiotics

Lipoic Acid Reverses Mitochondrial Decay

Nutraceutical Update - Rhodiola

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

 
Print Page
Email Article

Reduced insular gamma-aminobutyric acid [GABA] in fibromyalgia – Source: Arthritis & Rheumatism, Sep 13, 2011

  [ 58 votes ]   [ Discuss This Article ]
By BR Foerster, et al. • www.ProHealth.com • September 14, 2011


Objective: Recent scientific findings have re-invigorated interest in examining the role of gamma-aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions.

Decreased inhibitory neurotransmission is a proposed mechanism in the pathophysiology of chronic pain syndromes such as fibromyalgia (FM).

The purpose of this study was to test the hypothesis that decreased levels of insular and anterior cingulate GABA would be present in FM patients and the concentration of this neurotransmitter would be correlated with pressure pain thresholds.

Methods: Sixteen FM patients and 17 age- and sex-matched healthy controls underwent pressure pain testing and a 3 Tesla proton magnetic resonance spectroscopy session in which the right anterior insula, right posterior insula, anterior cingulate and occipital cortex were examined at rest.

Results:


Compared with healthy controls, FM patients had significantly lower levels of GABA in the right anterior insula (mean±SD 1.17±0.24 arbitrary institutional units versus 1.42±0.32 arbitrary institutional units; p=0.016).

There was a trend toward increased GABA levels in the anterior cingulate of FM patients versus healthy controls (p=0.06).

No significant differences between groups were detected in the posterior insula or occipital cortex (p>0.05 for all comparisons).

Within the right posterior insula, higher levels of GABA were positively correlated with pressure pain thresholds for the FM patients (rho=0.63; p=0.02).

Conclusion:
Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes.

Source: Arthritis & Rheumatism, Sep 13, 2011. PMID: 21913179, by Foerster BR, Petrou M, Edden RA, Phd PC, Schmidt-Wilcke T, Lowe SE, Phd SE, Clauw DJ, Harris RE. Department of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ann Arbor VA Healthcare System, Ann Arbor, Michigan. [Email: compfun@umich.edu]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Immune Support Supplements

Featured Products

L-Theanine Calm-Plex with GABA & 5-HTP (Suntheanine®) by ProHealth L-Theanine Calm-Plex with GABA & 5-HTP (Suntheanine®) by ProHealth
Synergistic Formula Enhances Mood & Well-being
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
GABA GABA
Natural Neurotransmitter Helps Reduce Stress
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing