ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Tests indicate some CFS linked to leaky gut & immune response to bacterial invasion

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 5, 2011


Article:
Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
– Source: Journal of Affective Disorders, Oct 1, 2011

By Michael Maes, et al.

[Note: commensal bacteria are the normally harmless populations of bacteria living in the gut. Translocation of these bacteria occurs when the gut lining breaks down, becoming more permeable, and bacteria leak out into the bloodstream. Cell-mediated immunity is a complex immune response against infected cells.]

Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by:

a. Systemic IgA/IgM responses against the lipopolysaccharides (LPS) of commensal bacteria;

b. Inflammation, e.g., increased plasma interleukin-(IL)1 and tumor necrosis factor (TNF)alpha; and

c. Activation of cell-mediated immunity (CMI), as demonstrated by increased neopterin.(1)

Methods:
To study the relationships between the IgA/IgM responses to the LPS of microbiota, inflammation, CMI and the symptoms of ME/CFS we measured the IgA/IgM responses to the LPS of 6 different enterobacteria, serum IL-1, TNF alpha, neopterin, and elastase in 128 patients with ME/CFS and chronic fatigue (CF).

Severity of symptoms was assessed by the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.

Results:

Serum IL-1, TNF alpha, neopterin and elastase are significantly higher in patients with ME/CFS than in CF patients.

There are significant and positive associations between the IgA responses to LPS and serum IL-1, TNF alpha, neopterin and elastase.

Patients with an abnormally high IgA response show increased serum IL-1, TNF alpha and neopterin levels, and higher ratings on irritable bowel syndrome (IBS) than subjects with a normal IgA response.

Serum IL-1, TNF alpha and neopterin are significantly related to fatigue, a flu-like malaise, autonomic symptoms, neurocognitive disorders, sadness and irritability.

Conclusions:
The findings show that increased IgA responses to commensal bacteria in ME/CFS are associated with inflammation and cell mediated immunity activation, which are associated with symptom severity.

It is concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.

Source: Journal of Affective Disorders, Oct 1, 2011. PMID: 21967891, by Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M. Maes Clinics @ TRIA, Bangkok, Thailand.

1. See accompanying report, "Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)..." by Maes M, et al., Journal of Affective Disorders, Oct 3, 2011





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map